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    Gas7 growth arrest specific 7 [ Mus musculus (house mouse) ]

    Gene ID: 14457, updated on 3-Dec-2024

    Summary

    Official Symbol
    Gas7provided by MGI
    Official Full Name
    growth arrest specific 7provided by MGI
    Primary source
    MGI:MGI:1202388
    See related
    Ensembl:ENSMUSG00000033066 AllianceGenome:MGI:1202388
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gas7-cb; B230343A10Rik
    Summary
    Enables actin filament binding activity. Acts upstream of or within actin filament organization; neuron projection morphogenesis; and regulation of cell shape. Located in actin filament and ruffle. Is expressed in forebrain. Orthologous to human GAS7 (growth arrest specific 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in cortex adult (RPKM 37.9), cerebellum adult (RPKM 29.9) and 15 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Gas7 in Genome Data Viewer
    Location:
    11 B3; 11 41.13 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (67344083..67579818)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (67453257..67688992)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene myosin, heavy polypeptide 13, skeletal muscle Neighboring gene STARR-seq mESC enhancer starr_29800 Neighboring gene predicted gene, 40029 Neighboring gene predicted gene, 31459 Neighboring gene STARR-seq mESC enhancer starr_29801 Neighboring gene STARR-positive B cell enhancer ABC_E10680 Neighboring gene STARR-positive B cell enhancer ABC_E1827 Neighboring gene predicted gene 12301 Neighboring gene glucagon-like peptide 2 receptor Neighboring gene recoverin Neighboring gene STARR-seq mESC enhancer starr_29802 Neighboring gene GSG1-like 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in actin filament IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in clathrin-coated pit IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in clathrin-coated vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in ruffle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    growth arrest-specific protein 7
    Names
    growth arrest-specific 7 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109657.4NP_001103127.1  growth arrest-specific protein 7 isoform b

      See identical proteins and their annotated locations for NP_001103127.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) is shorter and has a distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AL596255, AL646097, AL662883
      Consensus CDS
      CCDS48821.1
      UniProtKB/Swiss-Prot
      Q60780, Q9QY25, Q9QY26, Q9QY34
      UniProtKB/TrEMBL
      Q3U432
      Related
      ENSMUSP00000104320.3, ENSMUST00000108680.3
      Conserved Domains (2) summary
      cd07649
      Location:154386
      F-BAR_GAS7; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Growth Arrest Specific protein 7
      pfam16623
      Location:49141
      WW_FCH_linker; Unstructured linker region between on GAS7 protein
    2. NM_001277079.1NP_001264008.1  growth arrest-specific protein 7 isoform c

      See identical proteins and their annotated locations for NP_001264008.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AK152149, AL646097, BU053145, CJ147966, CV562268
      Consensus CDS
      CCDS70210.1
      UniProtKB/Swiss-Prot
      Q60780, Q9QY25, Q9QY26, Q9QY34
      UniProtKB/TrEMBL
      B1ATI9
      Related
      ENSMUSP00001091663.1, ENSMUST00020183803.1
      Conserved Domains (2) summary
      cd07649
      Location:150382
      F-BAR_GAS7; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Growth Arrest Specific protein 7
      pfam16623
      Location:45137
      WW_FCH_linker; Unstructured linker region between on GAS7 protein
    3. NM_001277080.1NP_001264009.1  growth arrest-specific protein 7 isoform d

      See identical proteins and their annotated locations for NP_001264009.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate downstream start codon, compared to variant 1. The encoded isoform (d) is shorter and has a distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AK152149, AL646097, CJ146254, CJ147966, CV562268
      UniProtKB/TrEMBL
      Q6A075
      Conserved Domains (2) summary
      cd07649
      Location:91323
      F-BAR_GAS7; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Growth Arrest Specific protein 7
      pfam16623
      Location:3378
      WW_FCH_linker; Unstructured linker region between on GAS7 protein
    4. NM_001402818.1NP_001389747.1  growth arrest-specific protein 7 isoform e

      Status: VALIDATED

      Source sequence(s)
      AL596255, AL646097, AL662883
      UniProtKB/Swiss-Prot
      Q60780, Q9QY25, Q9QY26, Q9QY34
      UniProtKB/TrEMBL
      F6QB26
      Related
      ENSMUSP00000104321.3, ENSMUST00000108681.9
    5. NM_001402819.1NP_001389748.1  growth arrest-specific protein 7 isoform f

      Status: VALIDATED

      Source sequence(s)
      AL596255, AL646097, AL662883
      UniProtKB/Swiss-Prot
      Q60780, Q9QY25, Q9QY26, Q9QY34
    6. NM_001402821.1NP_001389750.1  growth arrest-specific protein 7 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL596255, AL646097, AL662883
      UniProtKB/Swiss-Prot
      Q60780, Q9QY25, Q9QY26, Q9QY34
      UniProtKB/TrEMBL
      B1ATI9
    7. NM_001402823.1NP_001389752.1  growth arrest-specific protein 7 isoform d

      Status: VALIDATED

      Source sequence(s)
      AL596255, AL646097, AL662883
      UniProtKB/TrEMBL
      Q6A075
    8. NM_001402824.1NP_001389753.1  growth arrest-specific protein 7 isoform d

      Status: VALIDATED

      Source sequence(s)
      AL596255, AL646097, AL662883
      UniProtKB/TrEMBL
      Q6A075
    9. NM_001402825.1NP_001389754.1  growth arrest-specific protein 7 isoform g

      Status: VALIDATED

      Source sequence(s)
      AL646097
      UniProtKB/TrEMBL
      Q6A075
    10. NM_008088.5NP_032114.2  growth arrest-specific protein 7 isoform a

      See identical proteins and their annotated locations for NP_032114.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AK076926, AK152149, AL596255, AL646097, CV562268
      UniProtKB/Swiss-Prot
      Q60780, Q9QY25, Q9QY26, Q9QY34
      UniProtKB/TrEMBL
      Q0VBR8
      Conserved Domains (2) summary
      cd07649
      Location:159391
      F-BAR_GAS7; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Growth Arrest Specific protein 7
      pfam16623
      Location:54146
      WW_FCH_linker; Unstructured linker region between on GAS7 protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      67344083..67579818
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245564.1XP_030101424.1  growth arrest-specific protein 7 isoform X5

      UniProtKB/TrEMBL
      Q6A075
      Conserved Domains (2) summary
      cd07649
      Location:91323
      F-BAR_GAS7; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Growth Arrest Specific protein 7
      pfam16623
      Location:3378
      WW_FCH_linker; Unstructured linker region between on GAS7 protein
    2. XM_017314262.1XP_017169751.1  growth arrest-specific protein 7 isoform X3

      UniProtKB/Swiss-Prot
      Q60780, Q9QY25, Q9QY26, Q9QY34
      UniProtKB/TrEMBL
      B1ATI9
      Related
      ENSMUSP00000038420.6, ENSMUST00000041611.12
      Conserved Domains (2) summary
      cd07649
      Location:150382
      F-BAR_GAS7; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Growth Arrest Specific protein 7
      pfam16623
      Location:45137
      WW_FCH_linker; Unstructured linker region between on GAS7 protein
    3. XM_006532209.1XP_006532272.1  growth arrest-specific protein 7 isoform X5

      See identical proteins and their annotated locations for XP_006532272.1

      UniProtKB/TrEMBL
      Q6A075
      Conserved Domains (2) summary
      cd07649
      Location:91323
      F-BAR_GAS7; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Growth Arrest Specific protein 7
      pfam16623
      Location:3378
      WW_FCH_linker; Unstructured linker region between on GAS7 protein
    4. XM_006532208.4XP_006532271.1  growth arrest-specific protein 7 isoform X4

      UniProtKB/TrEMBL
      Q3U8N2
      Conserved Domains (2) summary
      cd07649
      Location:110342
      F-BAR_GAS7; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Growth Arrest Specific protein 7
      pfam16623
      Location:1497
      WW_FCH_linker; Unstructured linker region between on GAS7 protein