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    Fbxw17 F-box and WD-40 domain protein 17 [ Mus musculus (house mouse) ]

    Gene ID: 109082, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Fbxw17provided by MGI
    Official Full Name
    F-box and WD-40 domain protein 17provided by MGI
    Primary source
    MGI:MGI:1923584
    See related
    Ensembl:ENSMUSG00000037816 AllianceGenome:MGI:1923584
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110064L07Rik
    Expression
    Ubiquitous expression in ovary adult (RPKM 8.9), subcutaneous fat pad adult (RPKM 8.3) and 27 other tissues See more
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    Genomic context

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    See Fbxw17 in Genome Data Viewer
    Location:
    13 A5; 13 25.72 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (50571874..50587817)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (50417835..50433781)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2H pseudogene Neighboring gene STARR-seq mESC enhancer starr_34487 Neighboring gene predicted gene 8742 Neighboring gene predicted gene, 40946 Neighboring gene STARR-seq mESC enhancer starr_34489 Neighboring gene NUT family member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. F-Box Protein FBXW17-Mediated Proteasomal Degradation of Protein Methyltransferase PRMT6 Exaggerates CSE-Induced Lung Epithelial Inflammation and Apoptosis. Li T, et al. Front Cell Dev Biol, 2021. PMID 33959602, Free PMC Article
    2. Systematic analysis and nomenclature of mammalian F-box proteins. Jin J, et al. Genes Dev, 2004 Nov 1. PMID 15520277, Free PMC Article
    3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    F-box and WD-40 domain protein 17

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175401.4 → NP_780610.2  F-box and WD-40 domain protein 17

      See identical proteins and their annotated locations for NP_780610.2

      Status: VALIDATED

      Source sequence(s)
      AK135553, BC040428, BX518527
      Consensus CDS
      CCDS36661.1
      UniProtKB/TrEMBL
      Q8CFE8
      Related
      ENSMUSP00000041750.5, ENSMUST00000046974.5
      Conserved Domains (3) summary
      COG2319
      Location:90 → 417
      WD40; WD40 repeat [General function prediction only]
      pfam12937
      Location:7 → 48
      F-box-like; F-box-like
      sd00039
      Location:151 → 186
      7WD40; WD40 repeat [structural motif]

    RNA

    1. NR_154272.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC165366
      Related
      ENSMUST00000176479.8

    2. NR_154273.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC165366

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      50571874..50587817
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516829.2 → XP_006516892.1  F-box and WD-40 domain protein 17 isoform X3

      Conserved Domains (2) summary
      COG2319
      Location:48 → 375
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:109 → 144
      7WD40; WD40 repeat [structural motif]

    2. XM_006516832.2 → XP_006516895.1  F-box and WD-40 domain protein 17 isoform X6

      See identical proteins and their annotated locations for XP_006516895.1

      Conserved Domains (2) summary
      COG2319
      Location:12 → 339
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:73 → 108
      7WD40; WD40 repeat [structural motif]

    3. XM_030247125.1 → XP_030102985.1  F-box and WD-40 domain protein 17 isoform X7

      Conserved Domains (2) summary
      COG2319
      Location:12 → 172
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:73 → 108
      7WD40; WD40 repeat [structural motif]

    4. XM_006516833.2 → XP_006516896.1  F-box and WD-40 domain protein 17 isoform X6

      See identical proteins and their annotated locations for XP_006516896.1

      Conserved Domains (2) summary
      COG2319
      Location:12 → 339
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:73 → 108
      7WD40; WD40 repeat [structural motif]

    5. XM_006516828.4 → XP_006516891.1  F-box and WD-40 domain protein 17 isoform X2

      Conserved Domains (3) summary
      COG2319
      Location:90 → 250
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:151 → 186
      7WD40; WD40 repeat [structural motif]
      pfam12937
      Location:7 → 46
      F-box-like

    6. XM_006516830.5 → XP_006516893.1  F-box and WD-40 domain protein 17 isoform X4

      Conserved Domains (3) summary
      COG2319
      Location:90 → 250
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:151 → 186
      7WD40; WD40 repeat [structural motif]
      pfam12937
      Location:7 → 46
      F-box-like

    7. XM_006516831.4 → XP_006516894.1  F-box and WD-40 domain protein 17 isoform X5

      Conserved Domains (3) summary
      COG2319
      Location:90 → 250
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:151 → 186
      7WD40; WD40 repeat [structural motif]
      pfam12937
      Location:7 → 46
      F-box-like

    8. XM_006516827.2 → XP_006516890.1  F-box and WD-40 domain protein 17 isoform X1

      Conserved Domains (2) summary
      COG2319
      Location:69 → 396
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:130 → 165
      7WD40; WD40 repeat [structural motif]

    9. XM_036157831.1 → XP_036013724.1  F-box and WD-40 domain protein 17 isoform X6

      Conserved Domains (2) summary
      COG2319
      Location:12 → 339
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:73 → 108
      7WD40; WD40 repeat [structural motif]

    10. XM_036157832.1 → XP_036013725.1  F-box and WD-40 domain protein 17 isoform X6

      Conserved Domains (2) summary
      COG2319
      Location:12 → 339
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:73 → 108
      7WD40; WD40 repeat [structural motif]

    RNA

    1. XR_004937931.1 RNA Sequence

    2. XR_004937932.1 RNA Sequence

    3. XR_004937927.1 RNA Sequence

    4. XR_004937929.1 RNA Sequence

    5. XR_004937930.1 RNA Sequence

    6. XR_004937928.1 RNA Sequence

    7. XR_003950416.2 RNA Sequence

    8. XR_003950420.2 RNA Sequence

    9. XR_003950412.1 RNA Sequence

    10. XR_003950413.1 RNA Sequence

    11. XR_003950414.1 RNA Sequence

    12. XR_382225.4 RNA Sequence

    13. XR_382223.4 RNA Sequence

    14. XR_382224.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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