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    Adgrg7 adhesion G protein-coupled receptor G7 [ Mus musculus (house mouse) ]

    Gene ID: 239853, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adgrg7provided by MGI
    Official Full Name
    adhesion G protein-coupled receptor G7provided by MGI
    Primary source
    MGI:MGI:2441732
    See related
    Ensembl:ENSMUSG00000022755 AllianceGenome:MGI:2441732
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gpr128; 9130020O16Rik
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in gallbladder; large intestine; and testis. Orthologous to human ADGRG7 (adhesion G protein-coupled receptor G7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in large intestine adult (RPKM 13.6), colon adult (RPKM 8.1) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Adgrg7 in Genome Data Viewer
    Location:
    16 C1.1; 16 34.22 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (56544972..56616369, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (56724609..56796006, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene ABI family member 3 binding protein Neighboring gene STARR-seq mESC enhancer starr_41065 Neighboring gene STARR-seq mESC enhancer starr_41066 Neighboring gene STARR-seq mESC enhancer starr_41067 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:56717659-56717768 Neighboring gene STARR-seq mESC enhancer starr_41068 Neighboring gene Trk-fused gene Neighboring gene predicted gene 15693 Neighboring gene transmembrane protein 45a Neighboring gene STARR-seq mESC enhancer starr_41071 Neighboring gene programmed cell death 6 interacting protein pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Deletion of Gpr128 results in weight loss and increased intestinal contraction frequency. Ni YY, et al. World J Gastroenterol, 2014 Jan 14. PMID 24574718, Free PMC Article
    2. Structure of BAI1/ELMO2 complex reveals an action mechanism of adhesion GPCRs via ELMO family scaffolds. Weng Z, et al. Nat Commun, 2019 Jan 3. PMID 30604775, Free PMC Article
    3. The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Bjarnadóttir TK, et al. Genomics, 2004 Jul. PMID 15203201
    4. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. Hamann J, et al. Pharmacol Rev, 2015. PMID 25713288, Free PMC Article
    5. The G protein-coupled receptor repertoires of human and mouse. Vassilatis DK, et al. Proc Natl Acad Sci U S A, 2003 Apr 15. PMID 12679517, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    adhesion G-protein coupled receptor G7
    Names
    G protein coupled receptor Gpr128
    G protein-coupled receptor 128
    probable G-protein coupled receptor 128

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172825.3 → NP_766413.2  adhesion G-protein coupled receptor G7 precursor

      See identical proteins and their annotated locations for NP_766413.2

      Status: VALIDATED

      Source sequence(s)
      CT025158
      Consensus CDS
      CCDS28225.1
      UniProtKB/Swiss-Prot
      A2RSY9, Q80T42, Q8BM96
      Related
      ENSMUSP00000023437.5, ENSMUST00000023437.5
      Conserved Domains (2) summary
      pfam01825
      Location:380 → 418
      GPS; GPCR proteolysis site, GPS, motif
      cl21561
      Location:430 → 710
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      56544972..56616369 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245899.2 → XP_011244201.1  adhesion G-protein coupled receptor G7 isoform X1

      Conserved Domains (3) summary
      cd14964
      Location:430 → 455
      7tm_GPCRs; TM helix 1 [structural motif]
      pfam01825
      Location:380 → 418
      GPS; GPCR proteolysis site, GPS, motif
      cl28897
      Location:428 → 459
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BM96.2 GenPept UniProtKB/Swiss-Prot:Q8BM96

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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