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    Sds serine dehydratase [ Mus musculus (house mouse) ]

    Gene ID: 231691, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sdsprovided by MGI
    Official Full Name
    serine dehydrataseprovided by MGI
    Primary source
    MGI:MGI:98270
    See related
    Ensembl:ENSMUSG00000029597 AllianceGenome:MGI:98270
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SDH; 4432411H13Rik
    Summary
    Predicted to enable ammonia-lyase activity; protein homodimerization activity; and pyridoxal phosphate binding activity. Predicted to be involved in carboxylic acid metabolic process and protein-containing complex assembly. Predicted to be located in cytosol and mitochondrion. Is expressed in several structures, including genitourinary system; immune system; liver; musculature; and stomach. Orthologous to human SDS (serine dehydratase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward liver adult (RPKM 181.2) See more
    Orthologs
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    Genomic context

    See Sds in Genome Data Viewer
    Location:
    5 F; 5 60.63 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (120614612..120621997)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (120476547..120483932)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene LIM homeobox protein 5 Neighboring gene serine dehydratase-like Neighboring gene phospholipase B domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E2173 Neighboring gene solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 Neighboring gene two pore channel 1 Neighboring gene STARR-seq mESC enhancer starr_14239 Neighboring gene IQ motif containing D

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3) 

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-serine ammonia-lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables L-serine ammonia-lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables L-serine ammonia-lyase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables pyridoxal phosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables threonine deaminase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in L-serine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in L-serine catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in L-serine catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in pyruvate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in pyruvate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    L-serine dehydratase/L-threonine deaminase
    Names
    L-serine deaminase
    L-threonine dehydratase
    TDH
    NP_663540.1
    XP_006530361.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145565.1NP_663540.1  L-serine dehydratase/L-threonine deaminase

      Status: PROVISIONAL

      Source sequence(s)
      BC021950
      Consensus CDS
      CCDS19619.1
      UniProtKB/Swiss-Prot
      Q8VBT2
      UniProtKB/TrEMBL
      Q3UEN6
      Related
      ENSMUSP00000064849.8, ENSMUST00000066540.14
      Conserved Domains (2) summary
      cd06448
      Location:10320
      L-Ser-dehyd; Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- , D-serine, or L-threonine to pyruvate/ketobutyrate and ammonia.
      pfam00291
      Location:10304
      PALP; Pyridoxal-phosphate dependent enzyme

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      120614612..120621997
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530298.4XP_006530361.1  L-serine dehydratase/L-threonine deaminase isoform X1

      Conserved Domains (1) summary
      cd06448
      Location:35345
      L-Ser-dehyd; Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- , D-serine, or L-threonine to pyruvate/ketobutyrate and ammonia.