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    Oas1b 2'-5' oligoadenylate synthetase 1B [ Mus musculus (house mouse) ]

    Gene ID: 23961, updated on 9-Dec-2024

    Summary

    Official Symbol
    Oas1bprovided by MGI
    Official Full Name
    2'-5' oligoadenylate synthetase 1Bprovided by MGI
    Primary source
    MGI:MGI:97430
    See related
    Ensembl:ENSMUSG00000029605 AllianceGenome:MGI:97430
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    L1; Flv; Wnv; Oas1; Oias2; Mmu-L1; Oias-2
    Summary
    This gene is a member of the 2'-5' oligoA synthetase family, which are clustered on chromosome 5. The encoded protein functions in the interferon-regulated OAS/RNase L system, which mediates RNA decay as part of the innate antiviral immunity pathway. The protein binds double-stranded RNA and oligomerizes ATP, which activate the single-stranded RNA cleavage enzyme RNase L. This protein mediates resistance to flaviviruses such as West Nile virus. The majority of wild mouse strains produce a functional protein and are resistant to flavivirus infection, whereas some inbred mouse strains including the strain of the reference genome, C57BL/6J, contain a premature stop codon that inactivates this gene product. [provided by RefSeq, Jul 2008]
    Annotation information
    Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
    Expression
    Broad expression in thymus adult (RPKM 8.0), spleen adult (RPKM 5.8) and 22 other tissues See more
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    Genomic context

    See Oas1b in Genome Data Viewer
    Location:
    5 F; 5 60.64 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (120950700..120962228)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (120812635..120824163)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene 2'-5' oligoadenylate synthetase 1E Neighboring gene 2'-5' oligoadenylate synthetase 1C Neighboring gene STARR-positive B cell enhancer ABC_E1306 Neighboring gene STARR-seq mESC enhancer starr_14251 Neighboring gene STARR-seq mESC enhancer starr_14253 Neighboring gene 2'-5' oligoadenylate synthetase 1F Neighboring gene 2'-5' oligoadenylate synthetase 1H

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NOT enables 2'-5'-oligoadenylate synthetase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables 2'-5'-oligoadenylate synthetase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables double-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in antiviral innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in antiviral innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to interferon-alpha ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to interferon-beta ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in defense response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glucose metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in interleukin-27-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of IP-10 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of chemokine (C-X-C motif) ligand 2 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of type I interferon-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of viral genome replication IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of viral genome replication IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cellular respiration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interferon-beta production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of monocyte chemotactic protein-1 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein complex oligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of ribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to virus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to virus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in surfactant homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in toll-like receptor 3 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in toll-like receptor 4 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in type I interferon-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in type I interferon-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    colocalizes_with cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ribosome ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    inactive 2'-5'-oligoadenylate synthase 1B
    Names
    (2-5')oligo(A) synthase 1B
    (2-5')oligo(A) synthetase 1b
    2'-5'-oligoadenylate synthase-like protein 1
    2'-5'-oligoadenylate synthetase-like protein 1
    2-5A synthase 1B
    2-5A synthetase 1B
    Flavivirus resistance

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083925.1NP_001077394.1  inactive 2'-5'-oligoadenylate synthase 1B

      See identical proteins and their annotated locations for NP_001077394.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, coding) represents the functional allele that is not present in some strains, including the strain of the reference genome.
      Source sequence(s)
      AF418005
      UniProtKB/TrEMBL
      A8YPC3, A8YPE4, A8YPE6
      Conserved Domains (2) summary
      pfam10421
      Location:159343
      OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
      cl11966
      Location:30177
      NT_Pol-beta-like; Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins

    RNA

    1. NR_003507.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, non-coding) contains a premature stop codon, and represents the non-functional allele present in some strains, including the strain of the reference genome. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, coding, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC115937, AI326028, AK080152
      Related
      ENSMUST00000183291.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      120950700..120962228
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)