U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Dtx1 deltex 1, E3 ubiquitin ligase [ Mus musculus (house mouse) ]

    Gene ID: 14357, updated on 3-Dec-2024

    Summary

    Official Symbol
    Dtx1provided by MGI
    Official Full Name
    deltex 1, E3 ubiquitin ligaseprovided by MGI
    Primary source
    MGI:MGI:1352744
    See related
    Ensembl:ENSMUSG00000029603 AllianceGenome:MGI:1352744
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fxit1; mKIAA4160
    Summary
    Predicted to enable Notch binding activity; ubiquitin protein ligase activity; and ubiquitin protein ligase binding activity. Acts upstream of or within several processes, including Notch signaling pathway; cellular response to leukemia inhibitory factor; and negative regulation of T cell differentiation. Predicted to be located in cytosol and nuclear body. Predicted to be active in nucleoplasm. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Orthologous to human DTX1 (deltex E3 ubiquitin ligase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in spleen adult (RPKM 82.7), CNS E18 (RPKM 30.0) and 14 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Dtx1 in Genome Data Viewer
    Location:
    5 F; 5 60.64 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (120818268..120850879, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (120680203..120711867, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene DEAD box helicase 54 Neighboring gene cilia and flagella associated protein 73 Neighboring gene STARR-positive B cell enhancer ABC_E4782 Neighboring gene RAS protein activator like 1 (GAP1 like) Neighboring gene STARR-positive B cell enhancer ABC_E11300 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:121135771-121135981 Neighboring gene STARR-positive B cell enhancer ABC_E8075 Neighboring gene STARR-positive B cell enhancer ABC_E6371 Neighboring gene STARR-seq mESC enhancer starr_14247 Neighboring gene STARR-seq mESC enhancer starr_14249 Neighboring gene 2'-5' oligoadenylate synthetase 2 Neighboring gene 2'-5' oligoadenylate synthetase 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:121225553-121225736 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:121225792-121225979

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA4160

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Notch binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables Notch binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase DTX1
    Names
    FXI-T1
    RING-type E3 ubiquitin transferase DTX1
    deltex 1 homolog
    deltex1
    fractionated x-irradiation induced transcript 1
    mDTX1
    protein deltex-1
    NP_001404401.1
    NP_001404402.1
    NP_001404403.1
    NP_032078.2
    XP_011246483.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417472.1NP_001404401.1  E3 ubiquitin-protein ligase DTX1 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC115937, AC125183
      UniProtKB/TrEMBL
      Q5DTK6
    2. NM_001417473.1NP_001404402.1  E3 ubiquitin-protein ligase DTX1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC115937, AC125183
      UniProtKB/Swiss-Prot
      Q3TER5, Q61010, Q8C2H2, Q9ER09
      UniProtKB/TrEMBL
      Q5DTK6
    3. NM_001417474.1NP_001404403.1  E3 ubiquitin-protein ligase DTX1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC125183
      UniProtKB/Swiss-Prot
      Q3TER5, Q61010, Q8C2H2, Q9ER09
      UniProtKB/TrEMBL
      Q5DTK6
    4. NM_008052.4NP_032078.2  E3 ubiquitin-protein ligase DTX1 isoform b

      See identical proteins and their annotated locations for NP_032078.2

      Status: VALIDATED

      Source sequence(s)
      AC115937, AC125183
      Consensus CDS
      CCDS19624.1
      UniProtKB/Swiss-Prot
      Q3TER5, Q61010, Q8C2H2, Q9ER09
      UniProtKB/TrEMBL
      Q5DTK6
      Related
      ENSMUSP00000031607.7, ENSMUST00000031607.7
      Conserved Domains (3) summary
      smart00678
      Location:26102
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd16671
      Location:415483
      RING-H2_DTX1_4; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase deltex1 (DTX1), deltex4 (DTX4), and similar proteins
      pfam18102
      Location:486620
      DTC; Deltex C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      120818268..120850879 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248181.4XP_011246483.1  E3 ubiquitin-protein ligase DTX1 isoform X1

      See identical proteins and their annotated locations for XP_011246483.1

      UniProtKB/TrEMBL
      Q5DTK6
      Conserved Domains (3) summary
      smart00678
      Location:26102
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd16671
      Location:415487
      RING-H2_DTX1_4; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase deltex1 (DTX1), deltex4 (DTX4), and similar proteins
      pfam18102
      Location:490624
      DTC; Deltex C-terminal domain