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    Impdh2 inosine monophosphate dehydrogenase 2 [ Mus musculus (house mouse) ]

    Gene ID: 23918, updated on 9-Dec-2024

    Summary

    Official Symbol
    Impdh2provided by MGI
    Official Full Name
    inosine monophosphate dehydrogenase 2provided by MGI
    Primary source
    MGI:MGI:109367
    See related
    Ensembl:ENSMUSG00000062867 AllianceGenome:MGI:109367
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IMPD; IMPD 2; IMPDH-II
    Summary
    Enables IMP dehydrogenase activity. Involved in 'de novo' XMP biosynthetic process and GMP biosynthetic process. Acts upstream of or within cellular response to interleukin-4; lymphocyte proliferation; and purine nucleotide biosynthetic process. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; heart; respiratory system; and sensory organ. Orthologous to human IMPDH2 (inosine monophosphate dehydrogenase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 65.1), liver E14.5 (RPKM 58.3) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Impdh2 in Genome Data Viewer
    Location:
    9 F2; 9 59.5 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (108437635..108442776)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (108560436..108565577)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3860 Neighboring gene glutaminyl-tRNA synthetase 1 Neighboring gene glutamine-rich 1 Neighboring gene STARR-positive B cell enhancer ABC_E3861 Neighboring gene STARR-positive B cell enhancer ABC_E3862 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 3 Neighboring gene DALR anticodon binding domain containing 3 Neighboring gene microRNA 191

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables IMP dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables IMP dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables IMP dehydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables IMP dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleotide binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in 'de novo' XMP biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in GMP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in GMP biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in GMP salvage TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in GTP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in GTP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in GTP biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within cellular response to interleukin-4 IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in circadian rhythm ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in circadian rhythm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within lymphocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within purine nucleotide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    inosine-5'-monophosphate dehydrogenase 2
    Names
    IMP dehydrogenase 2
    IMP dehydrogenase type II
    inosine 5'-phosphate dehydrogenase 2
    NP_001365850.1
    NP_035960.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001378921.1NP_001365850.1  inosine-5'-monophosphate dehydrogenase 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      CT010508
      UniProtKB/TrEMBL
      Q3U9N8, Q3UPJ2
      Conserved Domains (1) summary
      PTZ00314
      Location:16534
      PTZ00314; inosine-5'-monophosphate dehydrogenase; Provisional
    2. NM_011830.5NP_035960.2  inosine-5'-monophosphate dehydrogenase 2 isoform 2

      See identical proteins and their annotated locations for NP_035960.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      CT010508
      Consensus CDS
      CCDS40768.1
      UniProtKB/Swiss-Prot
      P24547, Q61734, Q91Z11
      UniProtKB/TrEMBL
      Q3U9N8, Q3UAT9, Q3UPJ2
      Related
      ENSMUSP00000079888.9, ENSMUST00000081111.14
      Conserved Domains (1) summary
      PTZ00314
      Location:16510
      PTZ00314; inosine-5'-monophosphate dehydrogenase; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      108437635..108442776
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)