U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    SPC42 Spc42p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853824, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    SPC42
    Official Full Name
    Spc42p
    Primary source
    SGD:S000001525
    Locus tag
    YKL042W
    See related
    AllianceGenome:SGD:S000001525; FungiDB:YKL042W; VEuPathDB:YKL042W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    A structural constituent of cytoskeleton. Involved in spindle pole body duplication. Located in central plaque of spindle pole body and intermediate layer of spindle pole body. [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See SPC42 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (358475..359566)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Mmo1p Neighboring gene Phd1p Neighboring gene ESCRT-III subunit protein VPS24 Neighboring gene Nfu1p

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Transient sister chromatid separation and elastic deformation of chromosomes during mitosis in budding yeast. He X, et al. Cell, 2000 Jun 23. PMID 10892747
    2. Structure and function of Spc42 coiled-coils in yeast centrosome assembly and duplication. Drennan AC, et al. Mol Biol Cell, 2019 Jun 1. PMID 30969903, Free PMC Article
    3. The yeast protein kinase Mps1p is required for assembly of the integral spindle pole body component Spc42p. Castillo AR, et al. J Cell Biol, 2002 Feb 4. PMID 11827982, Free PMC Article
    4. Cdc28/Cdk1 regulates spindle pole body duplication through phosphorylation of Spc42 and Mps1. Jaspersen SL, et al. Dev Cell, 2004 Aug. PMID 15296722
    5. Delayed Encounter of Parental Genomes Can Lead to Aneuploidy in Saccharomyces cerevisiae. Tartakoff AM, et al. Genetics, 2018 Jan. PMID 29150427, Free PMC Article

    See all (73) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables structural constituent of cytoskeleton IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in spindle pole body duplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in central plaque of spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intermediate layer of spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle pole body IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Spc42p
    NP_012882.3
    • Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      358475..359566
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179608.3 → NP_012882.3  TPA: Spc42p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012882.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZZS3, B3LR46, C7GP31, C8ZCC8, D6VXP4, E7KEZ1, P36094
      UniProtKB/TrEMBL
      N1NZ93
      Conserved Domains (1) summary
      pfam11544
      Location:63 → 129
      Spc42p; Spindle pole body component Spc42p
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36094.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools