Hnrnpa3 heterogeneous nuclear ribonucleoprotein A3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hnrnpa3provided by RGD
Official Full Name: heterogeneous nuclear ribonucleoprotein A3provided by RGD
Primary source: RGD:727807
See related: EnsemblRapid:ENSRNOG00000052968 AllianceGenome:RGD:727807
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: mBx; Hnrpa3
Summary: Enables RNA transmembrane transporter activity and mRNA binding activity. Involved in mRNA transport. Located in ribonucleoprotein granule. Part of ribonucleoprotein complex. Is active in glutamatergic synapse and postsynaptic density. Biomarker of silicosis. Orthologous to human HNRNPA3 (heterogeneous nuclear ribonucleoprotein A3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 585.1), Spleen (RPKM 439.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q23

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (80984470..80999413)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (60578574..60588755)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (62481222..62491356)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neurons in the hippocampus of C9orf72 patients are frequently devoid of hnRNPA3. Reduced nuclear hnRNPA3 in the hippocampus of patients with extended C9orf72 repeats correlates with increased DPR deposition.
Title: Reduced hnRNPA3 increases C9orf72 repeat RNA levels and dipeptide-repeat protein deposition.
has a role in cytoplasmic trafficking of RNA (heterogenous nuclear ribonucleoprotein A3)
Title: Heterogeneous nuclear ribonucleoprotein A3, a novel RNA trafficking response element-binding protein.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Hnrpa3 (e-PCR), detects polymorphism
- UniSTS:479004

RH139237 (e-PCR)
- UniSTS:221323

RH136328 (e-PCR)
- UniSTS:210318

RH127548 (e-PCR)
- UniSTS:210858

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of catalytic step 2 spliceosome	IBA Inferred from Biological aspect of Ancestor more info
part_of catalytic step 2 spliceosome	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	EXP Inferred from Experiment more info	PubMed
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in postsynaptic density	EXP Inferred from Experiment more info	PubMed
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density	IMP Inferred from Mutant Phenotype more info	PubMed
part_of ribonucleoprotein complex	IDA Inferred from Direct Assay more info	PubMed
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
located_in ribonucleoprotein granule	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: heterogeneous nuclear ribonucleoprotein A3

Names: hnRNP A3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001111294.1 → NP_001104764.1 heterogeneous nuclear ribonucleoprotein A3 isoform a

See identical proteins and their annotated locations for NP_001104764.1

Status: VALIDATED

Source sequence(s)

AT006305, AW534817, BC081878, BI292197, BP488086, CB585714, CF110612, CF110891, CV107265, CV109437

UniProtKB/Swiss-Prot

Q6URK3, Q6URK4

UniProtKB/TrEMBL

A6HME5, D4A6A2

Related

ENSRNOP00000079420.2, ENSRNOT00000097068.2

Conserved Domains (3) summary

pfam11627
Location:332 → 348

HnRNPA1; Nuclear factor hnRNPA1

cd12578
Location:36 → 113

RRM1_hnRNPA_like; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A subfamily

cd12582
Location:126 → 205

RRM2_hnRNPA3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins
NM_001111295.1 → NP_001104765.1 heterogeneous nuclear ribonucleoprotein A3 isoform b

See identical proteins and their annotated locations for NP_001104765.1

Status: VALIDATED

Source sequence(s)

BC081878, CB585714, CB725005

UniProtKB/TrEMBL

A6HME9, D4A6A2

Conserved Domains (3) summary

pfam11627
Location:310 → 326

HnRNPA1; Nuclear factor hnRNPA1

cd12582
Location:104 → 183

RRM2_hnRNPA3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins

cd12763
Location:11 → 91

RRM1_hnRNPA3; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins
NM_198132.3 → NP_937765.1 heterogeneous nuclear ribonucleoprotein A3 isoform a

See identical proteins and their annotated locations for NP_937765.1

Status: VALIDATED

Source sequence(s)

BC081878, CB585714

UniProtKB/Swiss-Prot

Q6URK3, Q6URK4

UniProtKB/TrEMBL

A6HME5, D4A6A2

Conserved Domains (3) summary

pfam11627
Location:332 → 348

HnRNPA1; Nuclear factor hnRNPA1

cd12578
Location:36 → 113

RRM1_hnRNPA_like; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A subfamily

cd12582
Location:126 → 205

RRM2_hnRNPA3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

80984470..80999413

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063284131.1 → XP_063140201.1 heterogeneous nuclear ribonucleoprotein A3 isoform X1

UniProtKB/Swiss-Prot

Q6URK3, Q6URK4

UniProtKB/TrEMBL

A6HME5, D4A6A2
XM_063284134.1 → XP_063140204.1 heterogeneous nuclear ribonucleoprotein A3 isoform X3

UniProtKB/TrEMBL

A6HME9, D4A6A2
XM_063284132.1 → XP_063140202.1 heterogeneous nuclear ribonucleoprotein A3 isoform X2
XM_008761911.4 → XP_008760133.1 heterogeneous nuclear ribonucleoprotein A3 isoform X3

See identical proteins and their annotated locations for XP_008760133.1

UniProtKB/TrEMBL

A6HME9, D4A6A2

Conserved Domains (3) summary

pfam11627
Location:310 → 326

HnRNPA1; Nuclear factor hnRNPA1

cd12582
Location:104 → 183

RRM2_hnRNPA3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins

cd12763
Location:11 → 91

RRM1_hnRNPA3; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins
XM_008761912.4 → XP_008760134.1 heterogeneous nuclear ribonucleoprotein A3 isoform X3

See identical proteins and their annotated locations for XP_008760134.1

UniProtKB/TrEMBL

A6HME9, D4A6A2

Conserved Domains (3) summary

pfam11627
Location:310 → 326

HnRNPA1; Nuclear factor hnRNPA1

cd12582
Location:104 → 183

RRM2_hnRNPA3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins

cd12763
Location:11 → 91

RRM1_hnRNPA3; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins