Rhcg Rh family, C glycoprotein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rhcgprovided by RGD
Official Full Name: Rh family, C glycoproteinprovided by RGD
Primary source: RGD:727859
See related: EnsemblRapid:ENSRNOG00000015526 AllianceGenome:RGD:727859
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables ammonium channel activity. Involved in ammonium transmembrane transport. Located in apical plasma membrane; basolateral plasma membrane; and cytoplasmic vesicle. Biomarker of hypokalemia; kidney failure; and metabolic acidosis. Orthologous to human RHCG (Rh family C glycoprotein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 389.7) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q31

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (142941046..142965242, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (133531704..133555902, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (141325854..141349881, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Increased plasma membrane Rhcg expression in response to hypokalemia in the rat, particularly in the outer medullary collecting duct, likely contributes to the increased ammonia excretion and thereby to the development of metabolic alkalosis.
Title: Effect of hypokalemia on renal expression of the ammonia transporter family members, Rh B Glycoprotein and Rh C Glycoprotein, in the rat kidney.
Expression of Rhbg and Rhcg parallels intercalated cell development and that immature Rhbg and Rhcg expression at birth contributes to incomplete ammonia excretion capacity.
Title: Expression of ammonia transporter family members, Rh B glycoprotein and Rh C glycoprotein, in the developing rat kidney.
Altered subcellular localization of Rhcg contributes to adaptive changes in single-nephron ammonia metabolism and maintenance of acid-base homeostasis in response to reduced renal mass.
Title: Effect of reduced renal mass on renal ammonia transporter family, Rh C glycoprotein and Rh B glycoprotein, expression.
We conclude that chronic metabolic acidosis increases Rhcg protein expression in intercalated cells in the OMCD and in the IMCD, where it is likely to mediate an important role in the increased urinary ammonia excretion.
Title: Renal expression of the ammonia transporters, Rhbg and Rhcg, in response to chronic metabolic acidosis.
chronic metabolic acidosis increases apical plasma membrane Rh type C glycoprotein(Rhcg) in both the intercalated cell and principal cell where it may contribute to enhanced apical ammonia secretion
Title: Changes in subcellular distribution of the ammonia transporter, Rhcg, in response to chronic metabolic acidosis.
Review. Animal studies show Rhcg has a role in transmembrane NH3 or NH4+ transport in epithelial cells.
Title: Rh glycoproteins in epithelial cells: lessons from rat and mice studies.
Review. In rat innder & outer kidney medulla, Rhcg has both apical & basolateral expression, increased by chronic metabolic acidosis. Rhcg is present in bile duct epithelia.
Title: Expression of the non-erythroid Rh glycoproteins in mammalian tissues.

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General gene information

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Markers

Rhcg (e-PCR), detects polymorphism
- UniSTS:178189

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ammonium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables ammonium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables ammonium channel activity	IEA Inferred from Electronic Annotation more info
enables ammonium channel activity	ISO Inferred from Sequence Orthology more info
enables ammonium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables ankyrin binding	IEA Inferred from Electronic Annotation more info
enables ankyrin binding	ISO Inferred from Sequence Orthology more info
enables ankyrin binding	ISS Inferred from Sequence or Structural Similarity more info
enables carbon dioxide transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables carbon dioxide transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables carbon dioxide transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ammonium homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in ammonium transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in ammonium transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in ammonium transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in ammonium transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in ammonium transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in biological_process	ND No biological Data available more info
involved_in carbon dioxide transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in intracellular monoatomic ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in intracellular monoatomic ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular monoatomic ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of pH	IEA Inferred from Electronic Annotation more info
involved_in regulation of pH	ISO Inferred from Sequence Orthology more info
involved_in transepithelial ammonium transport	IEA Inferred from Electronic Annotation more info
involved_in transepithelial ammonium transport	ISO Inferred from Sequence Orthology more info
involved_in transepithelial ammonium transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in basal plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ammonium transporter Rh type C

Names: Rh type C glycoprotein; Rhesus blood group-associated C glycoprotein; rh family type C glycoprotein; rhesus blood group family type C glycoprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_183053.1 → NP_898876.1 ammonium transporter Rh type C

See identical proteins and their annotated locations for NP_898876.1

Status: PROVISIONAL

Source sequence(s)

AY129073

UniProtKB/Swiss-Prot

Q7TNN9

UniProtKB/TrEMBL

A0A8I5Y844

Related

ENSRNOP00000021109.4, ENSRNOT00000021109.6

Conserved Domains (1) summary

cl03012
Location:61 → 436

Ammonium_transp; Ammonium Transporter Family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

142941046..142965242 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039105631.2 → XP_038961559.1 ammonium transporter Rh type C isoform X1

UniProtKB/TrEMBL

A0A8I5Y844, A6JC59, F1M794

Conserved Domains (1) summary

cl03012
Location:84 → 459

Ammonium_transp; Ammonium Transporter Family