Oxct2b 3-oxoacid CoA transferase 2B [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Oxct2bprovided by RGD
Full Name: 3-oxoacid CoA transferase 2Bprovided by RGD
Primary source: RGD:1306953
See related: EnsemblRapid:ENSRNOG00000077785 AllianceGenome:RGD:1306953
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Oxct2a; SCOT-t1
Summary: Predicted to enable succinyl-CoA:3-oxo-acid CoA-transferase activity. Predicted to be involved in cellular ketone body metabolic process. Predicted to be located in motile cilium. Predicted to be active in mitochondrion. Orthologous to human OXCT2 (3-oxoacid CoA-transferase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (140681746..140683500)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (135396632..135398386)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (140813957..140815711)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

succinyl-CoA:3-ketoacid CoA transferase in rat kidney mitochondria is affected by age and caloric restriction
Title: Effects of age and calorie restriction on tryptophan nitration, protein content, and activity of succinyl-CoA:3-ketoacid CoA transferase in rat kidney mitochondria.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables succinyl-CoA:3-oxo-acid CoA-transferase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in ketone body catabolic process	IEA Inferred from Electronic Annotation more info
involved_in ketone body metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in motile cilium	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: succinyl-CoA:3-ketoacid coenzyme A transferase 2A, mitochondrial

Names: 3-oxoacid CoA-transferase 2A; rCG31267-like; testis-specific succinyl-CoA:3-oxoacid CoA-transferase 1

NP_001012221.1

EC 2.8.3.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012221.1 → NP_001012221.1 succinyl-CoA:3-ketoacid coenzyme A transferase 2A, mitochondrial precursor

See identical proteins and their annotated locations for NP_001012221.1

Status: PROVISIONAL

Source sequence(s)

BC083681

UniProtKB/Swiss-Prot

Q5XIJ9

UniProtKB/TrEMBL

A6IS18

Related

ENSRNOP00000108186.1, ENSRNOT00000150838.1

Conserved Domains (3) summary

COG1788
Location:49 → 273

AtoD; Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid transport and metabolism]

COG4670
Location:38 → 515

YdiF; Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid transport and metabolism]

cl00339
Location:300 → 506

SugarP_isomerase; SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ...