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    Asb11 ankyrin repeat and SOCS box containing 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 302666, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Asb11provided by RGD
    Official Full Name
    ankyrin repeat and SOCS box containing 11provided by RGD
    Primary source
    RGD:1566298
    See related
    EnsemblRapid:ENSRNOG00000003452 AllianceGenome:RGD:1566298
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1566298
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in endoplasmic reticulum unfolded protein response; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein K11-linked ubiquitination. Predicted to be located in endoplasmic reticulum. Predicted to be part of Cul5-RING ubiquitin ligase complex. Orthologous to several human genes including ASB9 (ankyrin repeat and SOCS box containing 9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 215.3) and Heart (RPKM 140.5) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Asb11 in Genome Data Viewer
    Location:
    Xq14
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (33646389..33669790, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (30014485..30037808, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (31758294..31781863, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene U2 spliceosomal RNA Neighboring gene ankyrin repeat and SOCS box-containing 9 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class A Neighboring gene vascular endothelial growth factor D Neighboring gene ubiquitin-conjugating enzyme E2 K pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase. Andresen CA, et al. J Biol Chem, 2014 Jan 24. PMID 24337577, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum unfolded protein response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K11-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul5-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat and SOCS box protein 11
    Names
    ankyrin repeat and SOCS box containing 11, E3 ubiquitin protein ligase
    ankyrin repeat and SOCS box-containing protein 11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106962.2 → NP_001100432.1  ankyrin repeat and SOCS box protein 11 isoform 1

      See identical proteins and their annotated locations for NP_001100432.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A6K2K5, D3ZSF1
      Related
      ENSRNOP00000004693.2, ENSRNOT00000004693.7
      Conserved Domains (5) summary
      cd00204
      Location:37 → 154
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:138 → 229
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:37 → 89
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:37 → 66
      ANK; ANK repeat [structural motif]
      cl02533
      Location:253 → 294
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

    2. NM_001434014.1 → NP_001420943.1  ankyrin repeat and SOCS box protein 11 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A8I5ZSR2, A6K2K4

    3. NM_001434015.1 → NP_001420944.1  ankyrin repeat and SOCS box protein 11 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      33646389..33669790 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006256858.5 → XP_006256920.3  ankyrin repeat and SOCS box protein 11 isoform X1

      Related
      ENSRNOP00000098800.1, ENSRNOT00000131446.1

    2. XM_008773166.3 → XP_008771388.1  ankyrin repeat and SOCS box protein 11 isoform X2

      Conserved Domains (5) summary
      cd00204
      Location:28 → 145
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:129 → 220
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:28 → 80
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:28 → 57
      ANK; ANK repeat [structural motif]
      cl02533
      Location:244 → 285
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    Nucleotide Protein Strain
    Heading Accession and Version

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