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    Bcor BCL6 co-repressor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 317346, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Bcorprovided by RGD
    Official Full Name
    BCL6 co-repressorprovided by RGD
    Primary source
    RGD:1562735
    See related
    EnsemblRapid:ENSRNOG00000034240 AllianceGenome:RGD:1562735
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562735
    Summary
    Predicted to enable several functions, including heat shock protein binding activity; histone deacetylase binding activity; and transcription corepressor activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in several processes, including negative regulation of biomineral tissue development; negative regulation of transcription by RNA polymerase II; and specification of axis polarity. Predicted to act upstream of or within blastocyst hatching. Predicted to be located in nucleoplasm. Predicted to be part of BCOR complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in dental caries; eye disease (multiple); and gastrointestinal system cancer (multiple). Orthologous to several human genes including BCOR (BCL6 corepressor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 46.4), Lung (RPKM 39.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Bcor in Genome Data Viewer
    Location:
    Xq12
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (13282431..13402254)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (10609756..10729613)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (11570155..11692022)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102549122 Neighboring gene uncharacterized LOC134484123 Neighboring gene tRNA methyltransferase activator subunit 11-2, pseudogene 3 Neighboring gene U6 spliceosomal RNA Neighboring gene ribosomal protein L37A like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of molecular features correlating with tumor immunity in gastric cancer by multi-omics data analysis. He Y, et al. Ann Transl Med, 2020 Sep. PMID 33145269, Free PMC Article
    2. Inhibition of the transcriptional repressor complex Bcl-6/BCoR induces endothelial sprouting but does not promote tumor growth. Buchberger E, et al. Oncotarget, 2017 Jan 3. PMID 27880939, Free PMC Article
    3. Comprehensive mutation profiling of mucinous gastric carcinoma. Rokutan H, et al. J Pathol, 2016 Oct. PMID 27313181
    4. Genome-wide analysis of DNA methylation in subjects with type 1 diabetes identifies epigenetic modifications associated with proliferative diabetic retinopathy. Agardh E, et al. BMC Med, 2015 Aug 6. PMID 26248552, Free PMC Article
    5. Left-sided embryonic expression of the BCL-6 corepressor, BCOR, is required for vertebrate laterality determination. Hilton EN, et al. Hum Mol Genet, 2007 Jul 15. PMID 17517692

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within blastocyst hatching ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heart development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of bone mineralization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of tooth mineralization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in odontogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in roof of mouth development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in specification of axis polarity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of BCOR complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    BCL-6 corepressor
    Names
    Bcl6 interacting corepressor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191586.2 → NP_001178515.1  BCL-6 corepressor isoform 1

      See identical proteins and their annotated locations for NP_001178515.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A8I5XVI9, D4A2J9
      Related
      ENSRNOP00000098479.2, ENSRNOT00000120870.2
      Conserved Domains (5) summary
      cd14261
      Location:1632 → 1748
      PUFD; PCGF Ub-like fold discriminator of BCOR
      pfam05109
      Location:257 → 672
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00045
      Location:1465 → 1496
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:1469 → 1560
      Ank_2; Ankyrin repeats (3 copies)
      pfam15808
      Location:1203 → 1415
      BCOR; BCL-6 co-repressor, non-ankyrin-repeat region

    2. NM_001434114.1 → NP_001421043.1  BCL-6 corepressor isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A6K007

    3. NM_001434115.1 → NP_001421044.1  BCL-6 corepressor isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A6K007

    4. NM_001434116.1 → NP_001421045.1  BCL-6 corepressor isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A8I5XVI9, D4A2J9

    5. NM_001434117.1 → NP_001421046.1  BCL-6 corepressor isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A8I5XVI9, D4A2J9

    6. NM_001434118.1 → NP_001421047.1  BCL-6 corepressor isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A6K007

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      13282431..13402254
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099760.2 → XP_038955688.1  BCL-6 corepressor isoform X1

      Conserved Domains (5) summary
      cd14261
      Location:1632 → 1748
      PUFD; PCGF Ub-like fold discriminator of BCOR
      pfam05109
      Location:257 → 672
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00045
      Location:1465 → 1496
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:1469 → 1560
      Ank_2; Ankyrin repeats (3 copies)
      pfam15808
      Location:1203 → 1415
      BCOR; BCL-6 co-repressor, non-ankyrin-repeat region

    2. XM_063280048.1 → XP_063136118.1  BCL-6 corepressor isoform X3

      UniProtKB/TrEMBL
      A6K007

    3. XM_039099759.2 → XP_038955687.1  BCL-6 corepressor isoform X1

      Conserved Domains (5) summary
      cd14261
      Location:1632 → 1748
      PUFD; PCGF Ub-like fold discriminator of BCOR
      pfam05109
      Location:257 → 672
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00045
      Location:1465 → 1496
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:1469 → 1560
      Ank_2; Ankyrin repeats (3 copies)
      pfam15808
      Location:1203 → 1415
      BCOR; BCL-6 co-repressor, non-ankyrin-repeat region

    4. XM_063280047.1 → XP_063136117.1  BCL-6 corepressor isoform X3

    5. XM_039099762.2 → XP_038955690.1  BCL-6 corepressor isoform X1

      UniProtKB/TrEMBL
      A0A8I5XVI9, D4A2J9
      Conserved Domains (5) summary
      cd14261
      Location:1632 → 1748
      PUFD; PCGF Ub-like fold discriminator of BCOR
      pfam05109
      Location:257 → 672
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00045
      Location:1465 → 1496
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:1469 → 1560
      Ank_2; Ankyrin repeats (3 copies)
      pfam15808
      Location:1203 → 1415
      BCOR; BCL-6 co-repressor, non-ankyrin-repeat region

    6. XM_039099763.2 → XP_038955691.1  BCL-6 corepressor isoform X1

      UniProtKB/TrEMBL
      A0A8I5XVI9, D4A2J9
      Conserved Domains (5) summary
      cd14261
      Location:1632 → 1748
      PUFD; PCGF Ub-like fold discriminator of BCOR
      pfam05109
      Location:257 → 672
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00045
      Location:1465 → 1496
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:1469 → 1560
      Ank_2; Ankyrin repeats (3 copies)
      pfam15808
      Location:1203 → 1415
      BCOR; BCL-6 co-repressor, non-ankyrin-repeat region

    7. XM_039099766.2 → XP_038955694.1  BCL-6 corepressor isoform X3

      Conserved Domains (5) summary
      cd14261
      Location:1598 → 1714
      PUFD; PCGF Ub-like fold discriminator of BCOR
      pfam05109
      Location:257 → 672
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00045
      Location:1431 → 1462
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:1435 → 1526
      Ank_2; Ankyrin repeats (3 copies)
      pfam15808
      Location:1169 → 1381
      BCOR; BCL-6 co-repressor, non-ankyrin-repeat region

    8. XM_063280046.1 → XP_063136116.1  BCL-6 corepressor isoform X2

      UniProtKB/TrEMBL
      A0A8I5XVI9, A0A8I6A262

    9. XM_063280045.1 → XP_063136115.1  BCL-6 corepressor isoform X1

      UniProtKB/TrEMBL
      A0A8I5XVI9, D4A2J9

    10. XM_039099765.2 → XP_038955693.1  BCL-6 corepressor isoform X2

      UniProtKB/TrEMBL
      A0A8I5XVI9, A0A8I6A262
      Related
      ENSRNOP00000098480.2, ENSRNOT00000120871.2
      Conserved Domains (5) summary
      cd14261
      Location:1614 → 1730
      PUFD; PCGF Ub-like fold discriminator of BCOR
      pfam05109
      Location:257 → 672
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00045
      Location:1447 → 1478
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:1451 → 1542
      Ank_2; Ankyrin repeats (3 copies)
      pfam15808
      Location:1185 → 1397
      BCOR; BCL-6 co-repressor, non-ankyrin-repeat region

    11. XM_063280049.1 → XP_063136119.1  BCL-6 corepressor isoform X4

    12. XM_039099761.2 → XP_038955689.1  BCL-6 corepressor isoform X1

      UniProtKB/TrEMBL
      A0A8I5XVI9, D4A2J9
      Conserved Domains (5) summary
      cd14261
      Location:1632 → 1748
      PUFD; PCGF Ub-like fold discriminator of BCOR
      pfam05109
      Location:257 → 672
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00045
      Location:1465 → 1496
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:1469 → 1560
      Ank_2; Ankyrin repeats (3 copies)
      pfam15808
      Location:1203 → 1415
      BCOR; BCL-6 co-repressor, non-ankyrin-repeat region

    13. XM_039099764.2 → XP_038955692.1  BCL-6 corepressor isoform X1

      UniProtKB/TrEMBL
      A0A8I5XVI9, D4A2J9
      Conserved Domains (5) summary
      cd14261
      Location:1632 → 1748
      PUFD; PCGF Ub-like fold discriminator of BCOR
      pfam05109
      Location:257 → 672
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00045
      Location:1465 → 1496
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:1469 → 1560
      Ank_2; Ankyrin repeats (3 copies)
      pfam15808
      Location:1203 → 1415
      BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
    Nucleotide Protein Strain
    Heading Accession and Version

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