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    Slc4a1 solute carrier family 4 member 1 (Diego blood group) [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24779, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slc4a1provided by RGD
    Official Full Name
    solute carrier family 4 member 1 (Diego blood group)provided by RGD
    Primary source
    RGD:3710
    See related
    EnsemblRapid:ENSRNOG00000020951 AllianceGenome:RGD:3710
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables actin binding activity and enzyme binding activity. Involved in several processes, including response to acidic pH; response to alkaline pH; and response to hydrogen peroxide. Located in several cellular components, including Z disc; basolateral plasma membrane; and intercalated disc. Biomarker of iron deficiency anemia; metabolic acidosis; and renal tubular acidosis. Human ortholog(s) of this gene implicated in congenital hemolytic anemia; hereditary spherocytosis; and renal tubular acidosis. Orthologous to human SLC4A1 (solute carrier family 4 member 1 (Diego blood group)). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 1804.0) and Kidney (RPKM 205.4) See more
    Orthologs
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    Genomic context

    See Slc4a1 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (87807010..87823274, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (87306865..87323132, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (90296144..90312401, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene transmembrane and ubiquitin-like domain containing 2 Neighboring gene ataxin 7-like 3 Neighboring gene uncharacterized LOC134480881 Neighboring gene upstream binding transcription factor Neighboring gene partner of NOB1 homolog (S. cerevisiae), pseudogene 1 Neighboring gene RUN domain containing 3A

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Clone Names

    • MGC93554

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding PubMed 
    enables ankyrin binding  
    enables ankyrin binding  
    enables bicarbonate transmembrane transporter activity  
    enables bicarbonate transmembrane transporter activity  
    enables bicarbonate transmembrane transporter activity  
    enables chloride transmembrane transporter activity  
    enables chloride transmembrane transporter activity  
    enables chloride:bicarbonate antiporter activity  
    enables chloride:bicarbonate antiporter activity  
    enables chloride:bicarbonate antiporter activity  
    enables enzyme binding PubMed 
    enables hemoglobin binding  
    enables hemoglobin binding  
    enables monoatomic anion transmembrane transporter activity  
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    enables protein-containing complex binding PubMed 
    enables solute:inorganic anion antiporter activity  
    enables solute:inorganic anion antiporter activity  
    enables solute:inorganic anion antiporter activity  
    Items 1 - 25 of 40
    Process Evidence Code Pubs
    involved_in bicarbonate transport  
    involved_in bicarbonate transport  
    acts_upstream_of_or_within bicarbonate transport  
    involved_in bicarbonate transport  
    involved_in bicarbonate transport  
    involved_in bicarbonate transport PubMed 
    involved_in blood coagulation  
    acts_upstream_of_or_within blood coagulation  
    involved_in chloride transmembrane transport  
    involved_in chloride transmembrane transport  
    involved_in chloride transmembrane transport  
    involved_in chloride transport  
    involved_in chloride transport  
    involved_in chloride transport PubMed 
    involved_in circadian rhythm PubMed 
    involved_in erythrocyte development  
    acts_upstream_of_or_within erythrocyte development  
    involved_in inorganic anion transport  
    involved_in monoatomic anion transmembrane transport  
    involved_in negative regulation of glycolytic process through fructose-6-phosphate  
    acts_upstream_of_or_within negative regulation of glycolytic process through fructose-6-phosphate  
    acts_upstream_of_or_within negative regulation of oxidoreductase activity  
    involved_in negative regulation of urine volume  
    acts_upstream_of_or_within negative regulation of urine volume  
    involved_in pH elevation  
    acts_upstream_of_or_within pH elevation  
    involved_in plasma membrane phospholipid scrambling  
    acts_upstream_of_or_within plasma membrane phospholipid scrambling  
    involved_in positive regulation of T cell proliferation PubMed 
    involved_in protein localization to plasma membrane  
    acts_upstream_of_or_within protein localization to plasma membrane  
    involved_in regulation of intracellular pH  
    involved_in response to acidic pH PubMed 
    involved_in response to activity PubMed 
    involved_in response to alkaline pH PubMed 
    involved_in response to arsenic-containing substance PubMed 
    involved_in response to carbon dioxide PubMed 
    involved_in response to hydrogen peroxide PubMed 
    involved_in response to nutrient levels PubMed 
    involved_in transmembrane transport  
    Items 1 - 25 of 40
    Component Evidence Code Pubs
    located_in Z disc PubMed 
    part_of ankyrin-1 complex  
    part_of ankyrin-1 complex  
    part_of ankyrin-1 complex  
    is_active_in basolateral plasma membrane  
    located_in basolateral plasma membrane PubMed 
    located_in basolateral plasma membrane  
    located_in basolateral plasma membrane  
    located_in cell surface PubMed 
    located_in cortical cytoskeleton  
    located_in cortical cytoskeleton  
    located_in cortical cytoskeleton  
    located_in cytoplasmic side of plasma membrane  
    located_in cytoplasmic side of plasma membrane  
    located_in intercalated disc PubMed 
    located_in membrane  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    band 3 anion transport protein
    Names
    AE 1
    Solute carrier family 4, member 1, anion exchange protein 1 (kidney band 3)
    anion exchange protein 1
    anion exchanger 1
    solute carrier family 4 (anion exchanger), member 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012651.3NP_036783.2  band 3 anion transport protein

      See identical proteins and their annotated locations for NP_036783.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A0G2K8D8
      Related
      ENSRNOP00000028445.7, ENSRNOT00000028445.8
      Conserved Domains (3) summary
      TIGR00834
      Location:72927
      ae; anion exchange protein
      pfam00955
      Location:390856
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:100342
      Band_3_cyto; Band 3 cytoplasmic domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      87807010..87823274 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008767946.4XP_008766168.1  band 3 anion transport protein isoform X2

      See identical proteins and their annotated locations for XP_008766168.1

      UniProtKB/Swiss-Prot
      P23562
      UniProtKB/TrEMBL
      A0A0G2K8D8
      Related
      ENSRNOP00000074568.3, ENSRNOT00000092102.3
      Conserved Domains (3) summary
      TIGR00834
      Location:72926
      ae; anion exchange protein
      pfam00955
      Location:389855
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:100342
      Band_3_cyto; Band 3 cytoplasmic domain
    2. XM_063268427.1XP_063124497.1  band 3 anion transport protein isoform X1

      UniProtKB/TrEMBL
      A0A0G2K8D8
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