Adss2 adenylosuccinate synthase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adss2provided by RGD
Official Full Name: adenylosuccinate synthase 2provided by RGD
Primary source: RGD:1310508
See related: EnsemblRapid:ENSRNOG00000004481 AllianceGenome:RGD:1310508
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Adss
Summary: Enables adenylosuccinate synthase activity. Involved in several processes, including IMP metabolic process; aspartate metabolic process; and cellular response to electrical stimulus. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. Biomarker of sarcoma. Orthologous to human ADSS2 (adenylosuccinate synthase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 354.8), Thymus (RPKM 280.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q25

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (92301302..92331638, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (89769240..89799577, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (95913426..95943761, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

RH129208 (e-PCR)
- UniSTS:212516

RH142786 (e-PCR)
- UniSTS:232033

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables adenylosuccinate synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenylosuccinate synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables adenylosuccinate synthase activity	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 'de novo' AMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in 'de novo' AMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in 'de novo' AMP biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within AMP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in AMP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in IMP metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in IMP metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in aspartate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to electrical stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within purine nucleotide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in response to ammonium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to purine-containing compound	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: adenylosuccinate synthetase isozyme 2

Names: adenylosuccinate synthetase 2, non muscle; adenylosuccinate synthetase, non muscle

NP_001099445.1

EC 6.3.4.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001105975.1 → NP_001099445.1 adenylosuccinate synthetase isozyme 2

Status: PROVISIONAL

Source sequence(s)

CH473985

UniProtKB/TrEMBL

A0A8I6AT75, A6JGD7, D4AEP0

Related

ENSRNOP00000005961.5, ENSRNOT00000005961.7

Conserved Domains (1) summary

pfam00709
Location:32 → 453

Adenylsucc_synt; Adenylosuccinate synthetase