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    DSC2 Dsc2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854081, updated on 9-Dec-2024

    Summary

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    Official Symbol
    DSC2
    Official Full Name
    Dsc2p
    Primary source
    SGD:S000005434
    Locus tag
    YOL073C
    See related
    AllianceGenome:SGD:S000005434; FungiDB:YOL073C; VEuPathDB:YOL073C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Located in endoplasmic reticulum. Part of Dsc E3 ubiquitin ligase complex. Orthologous to human UBAC2 (UBA domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See DSC2 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (193832..194800, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Mdm20p Neighboring gene uncharacterized protein Neighboring gene Thp1p Neighboring gene succinate dehydrogenase assembly factor SDH5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Dsc ubiquitin ligase complex identifies transmembrane degrons to degrade orphaned proteins at the Golgi. Weyer Y, et al. Nat Commun, 2024 Oct 26. PMID 39461958, Free PMC Article
    2. Sorting of a multi-subunit ubiquitin ligase complex in the endolysosome system. Yang X, et al. Elife, 2018 Jan 22. PMID 29355480, Free PMC Article
    3. Identification of candidate substrates for the Golgi Tul1 E3 ligase using quantitative diGly proteomics in yeast. Tong Z, et al. Mol Cell Proteomics, 2014 Nov. PMID 25078903, Free PMC Article
    4. TOR complex 2 (TORC2) signaling and the ESCRT machinery cooperate in the protection of plasma membrane integrity in yeast. Schmidt O, et al. J Biol Chem, 2020 Aug 21. PMID 32611771, Free PMC Article
    5. Membrane-anchored ubiquitin ligase complex is required for the turnover of lysosomal membrane proteins. Li M, et al. J Cell Biol, 2015 Nov 9. PMID 26527740, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    part_of Dsc E3 ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Dsc2p
    NP_014568.1
    • Multi-transmembrane subunit of the DSC ubiquitin ligase complex; similar in sequence to rhomboid pseudoproteases Der1p and UBAC2 that function in ERAD; ortholog of fission yeast dsc2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      193832..194800 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183328.1 → NP_014568.1  TPA: Dsc2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014568.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1Z4, Q08232
      UniProtKB/TrEMBL
      A6ZND7, B3LIY7, B5VRI0, C7GK40, N1NWD2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08232.1

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