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    RPS10A ribosomal 40S subunit protein S10A [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854468, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RPS10A
    Official Full Name
    ribosomal 40S subunit protein S10A
    Primary source
    SGD:S000005819
    Locus tag
    YOR293W
    See related
    AllianceGenome:SGD:S000005819; FungiDB:YOR293W; VEuPathDB:YOR293W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Involved in ribosomal subunit export from nucleus. Predicted to be located in cytoplasm and ribosome. Predicted to be part of cytosolic small ribosomal subunit. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 9. Orthologous to several human genes including RPS10 (ribosomal protein S10). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RPS10A in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    2
    Sequence:
    Chromosome: XV; NC_001147.6 (867098..867852)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene putative acid anhydride hydrolase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Rrs1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rps26 directs mRNA-specific translation by recognition of Kozak sequence elements. Ferretti MB, et al. Nat Struct Mol Biol, 2017 Sep. PMID 28759050, Free PMC Article
    2. Cost-effective and rapid lysis of Saccharomyces cerevisiae cells for quantitative western blot analysis of proteins, including phosphorylated eIF2α. Lee SJ, et al. Yeast, 2017 Sep. PMID 28568773
    3. Gcn1 contacts the small ribosomal protein Rps10, which is required for full activation of the protein kinase Gcn2. Lee SJ, et al. Biochem J, 2015 Mar 15. PMID 25437641
    4. Genetic Regulation of Dna2 Localization During the DNA Damage Response. Yimit A, et al. G3 (Bethesda), 2015 Jul 10. PMID 26163422, Free PMC Article
    5. Ribosomal protein genes RPS10 and RPS26 are commonly mutated in Diamond-Blackfan anemia. Doherty L, et al. Am J Hum Genet, 2010 Feb 12. PMID 20116044, Free PMC Article

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in ribosomal subunit export from nucleus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytosolic small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic small ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal 40S subunit protein S10A
    NP_014936.1
    • Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication; mutations in the human homolog associated with Diamond-Blackfan anemia

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      867098..867852
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183712.1 → NP_014936.1  TPA: ribosomal 40S subunit protein S10A [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014936.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2Z1, Q08745
      UniProtKB/TrEMBL
      A6ZPC8, B3LJV7, C7GNW8, C8ZH43, G2WNF9, N1NYV2
      Conserved Domains (1) summary
      COG5045
      Location:1 → 105
      COG5045; Ribosomal protein S10E [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08745.1

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