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    St3gal6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 [ Mus musculus (house mouse) ]

    Gene ID: 54613, updated on 9-Dec-2024

    Summary

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    Official Symbol
    St3gal6provided by MGI
    Official Full Name
    ST3 beta-galactoside alpha-2,3-sialyltransferase 6provided by MGI
    Primary source
    MGI:MGI:1888707
    See related
    Ensembl:ENSMUSG00000022747 AllianceGenome:MGI:1888707
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Siat10; St3galVI; 1700023B24Rik
    Summary
    Predicted to enable N-acetyllactosaminide alpha-2,3-sialyltransferase activity and beta-galactoside (CMP) alpha-2,3-sialyltransferase activity. Predicted to be involved in cellular response to interleukin-6; glycolipid biosynthetic process; and protein glycosylation. Predicted to be located in Golgi membrane. Is expressed in dentate gyrus subgranular zone and early tubule. Orthologous to human ST3GAL6 (ST3 beta-galactoside alpha-2,3-sialyltransferase 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in colon adult (RPKM 4.2), lung adult (RPKM 3.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See St3gal6 in Genome Data Viewer
    Location:
    16 C1.2; 16 34.58 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (58290105..58344614, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (58469742..58524260, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41463 Neighboring gene STARR-seq mESC enhancer starr_41094 Neighboring gene STARR-seq mESC enhancer starr_41095 Neighboring gene RIKEN cDNA 4930461C15 gene Neighboring gene STARR-positive B cell enhancer ABC_E1928 Neighboring gene STARR-seq mESC enhancer starr_41096 Neighboring gene discoidin, CUB and LCCL domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E3167 Neighboring gene STARR-positive B cell enhancer ABC_E8639 Neighboring gene STARR-positive B cell enhancer ABC_E3168 Neighboring gene STARR-seq mESC enhancer starr_41097 Neighboring gene predicted gene, 20942 Neighboring gene STARR-seq mESC enhancer starr_41098 Neighboring gene ferritin domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Sialyltransferase ST3GAL6 silencing reduces α2,3-sialylated glycans to regulate autophagy by decreasing HSPB8-BAG3 in the brain with hepatic encephalopathy. Li X, et al. J Zhejiang Univ Sci B, 2024 May 15. PMID 38910494, Free PMC Article
    2. Coordinated roles of ST3Gal-VI and ST3Gal-IV sialyltransferases in the synthesis of selectin ligands. Yang WH, et al. Blood, 2012 Aug 2. PMID 22700726, Free PMC Article
    3. Combinatorial PCR approach to homology-based cloning: cloning and expression of mouse and human GM3-synthase. Kapitonov D, et al. Glycoconj J, 1999 Jul. PMID 10619706
    4. Innate mechanism of mucosal barrier erosion in the pathogenesis of acquired colitis. Yang WH, et al. iScience, 2023 Oct 20. PMID 37752945, Free PMC Article
    5. Comparison of genomic structures of four members of beta-galactoside alpha2,3-sialyltransferase genes in the mouse. Takashima S, et al. Cytogenet Cell Genet, 2000. PMID 10894948

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sialyltransferase ST3GAL6 silencing reduces alpha2,3-sialylated glycans to regulate autophagy by decreasing HSPB8-BAG3 in the brain with hepatic encephalopathy.
      Title: Sialyltransferase ST3GAL6 silencing reduces α2,3-sialylated glycans to regulate autophagy by decreasing HSPB8-BAG3 in the brain with hepatic encephalopathy.
    2. Coordinated participation of both ST3Gal-VI and ST3Gal-IV in the synthesis of functional selectin ligands.
      Title: Coordinated roles of ST3Gal-VI and ST3Gal-IV sialyltransferases in the synthesis of selectin ligands.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-acetyllactosaminide alpha-2,3-sialyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sialyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sialyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to interleukin-6 ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glycolipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolipid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein glycosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    type 2 lactosamine alpha-2,3-sialyltransferase
    Names
    CMP-NeuAc:beta-galactoside alpha-2,3-sialyltransferase VI
    ST3Gal VI
    alpha-2,3-sialyltransferase VI
    sialyltransferase 10 (alpha-2,3-sialyltransferase VI)
    NP_001344362.1
    NP_001344363.1
    NP_001344364.1
    NP_001390061.1
    NP_001390062.1
    NP_001390063.1
    NP_001390064.1
    NP_001390065.1
    NP_001390066.1
    NP_061254.1
    XP_011244276.1
    XP_011244277.1
    XP_011244278.1
    XP_030105054.1
    XP_036015919.1
    XP_036015920.1
    XP_036015921.1
    XP_036015922.1
    XP_036015923.1
    XP_036015924.1
    XP_036015925.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357433.2 → NP_001344362.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC154764, CT027564
      Consensus CDS
      CCDS28230.1
      UniProtKB/Swiss-Prot
      Q3TRN3, Q80UR7, Q8VIB3, Q9WVG2
      Related
      ENSMUSP00000109998.3, ENSMUST00000114358.9
      Conserved Domains (1) summary
      pfam00777
      Location:79 → 328
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    2. NM_001357434.2 → NP_001344363.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154764, CT027564
      Conserved Domains (1) summary
      pfam00777
      Location:69 → 318
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    3. NM_001357435.2 → NP_001344364.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC154764, CT027564
      Consensus CDS
      CCDS28230.1
      UniProtKB/Swiss-Prot
      Q3TRN3, Q80UR7, Q8VIB3, Q9WVG2
      Related
      ENSMUSP00000109997.4, ENSMUST00000114357.10
      Conserved Domains (1) summary
      pfam00777
      Location:79 → 328
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    4. NM_001403132.1 → NP_001390061.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC154764, CT027564
      UniProtKB/Swiss-Prot
      Q3TRN3, Q80UR7, Q8VIB3, Q9WVG2

    5. NM_001403133.1 → NP_001390062.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC154764, CT027564
      UniProtKB/Swiss-Prot
      Q3TRN3, Q80UR7, Q8VIB3, Q9WVG2

    6. NM_001403134.1 → NP_001390063.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC154764, CT027564
      UniProtKB/Swiss-Prot
      Q3TRN3, Q80UR7, Q8VIB3, Q9WVG2

    7. NM_001403135.1 → NP_001390064.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 1

      Status: VALIDATED

      Source sequence(s)
      CT027564
      UniProtKB/Swiss-Prot
      Q3TRN3, Q80UR7, Q8VIB3, Q9WVG2

    8. NM_001403136.1 → NP_001390065.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154764, CT027564

    9. NM_001403137.1 → NP_001390066.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT027564

    10. NM_018784.3 → NP_061254.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 1

      See identical proteins and their annotated locations for NP_061254.1

      Status: VALIDATED

      Source sequence(s)
      AC154764, CT027564
      Consensus CDS
      CCDS28230.1
      UniProtKB/Swiss-Prot
      Q3TRN3, Q80UR7, Q8VIB3, Q9WVG2
      Related
      ENSMUSP00000115756.2, ENSMUST00000137035.8
      Conserved Domains (1) summary
      pfam00777
      Location:79 → 328
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    RNA

    1. NR_175353.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154764, CT027564

    2. NR_175354.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154764, CT027564

    3. NR_175355.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154764, CT027564

    4. NR_175356.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154764, CT027564

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      58290105..58344614 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245975.3 → XP_011244277.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform X5

      Conserved Domains (1) summary
      pfam00777
      Location:69 → 318
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    2. XM_036160029.1 → XP_036015922.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform X4

      UniProtKB/Swiss-Prot
      Q3TRN3, Q80UR7, Q8VIB3, Q9WVG2
      Conserved Domains (1) summary
      pfam00777
      Location:79 → 328
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    3. XM_036160028.1 → XP_036015921.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform X4

      UniProtKB/Swiss-Prot
      Q3TRN3, Q80UR7, Q8VIB3, Q9WVG2
      Conserved Domains (1) summary
      pfam00777
      Location:79 → 328
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    4. XM_036160030.1 → XP_036015923.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform X4

      UniProtKB/Swiss-Prot
      Q3TRN3, Q80UR7, Q8VIB3, Q9WVG2
      Conserved Domains (1) summary
      pfam00777
      Location:79 → 328
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    5. XM_036160026.1 → XP_036015919.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform X2

      Conserved Domains (1) summary
      pfam00777
      Location:129 → 378
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    6. XM_030249194.1 → XP_030105054.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform X7

      Conserved Domains (1) summary
      pfam00777
      Location:5 → 254
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    7. XM_036160032.1 → XP_036015925.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform X4

      UniProtKB/Swiss-Prot
      Q3TRN3, Q80UR7, Q8VIB3, Q9WVG2
      Conserved Domains (1) summary
      pfam00777
      Location:79 → 328
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    8. XM_011245974.4 → XP_011244276.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform X4

      See identical proteins and their annotated locations for XP_011244276.1

      UniProtKB/Swiss-Prot
      Q3TRN3, Q80UR7, Q8VIB3, Q9WVG2
      Conserved Domains (1) summary
      pfam00777
      Location:79 → 328
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    9. XM_036160031.1 → XP_036015924.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform X6

      Conserved Domains (1) summary
      pfam00777
      Location:79 → 303
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    10. XM_011245976.4 → XP_011244278.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform X6

      Conserved Domains (1) summary
      pfam00777
      Location:79 → 303
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    11. XM_036160027.1 → XP_036015920.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform X3

      Conserved Domains (1) summary
      pfam00777
      Location:139 → 363
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    RNA

    1. XR_384577.5 RNA Sequence

    2. XR_003951805.2 RNA Sequence

    3. XR_003951802.2 RNA Sequence

    4. XR_004939201.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VIB3.3 GenPept UniProtKB/Swiss-Prot:Q8VIB3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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