GTO1 omega-class glutathione transferase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: GTO1
Official Full Name: omega-class glutathione transferase
Primary source: SGD:S000003386
Locus tag: YGR154C
See related: AllianceGenome:SGD:S000003386; FungiDB:YGR154C; VEuPathDB:YGR154C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables glutathione transferase activity. Predicted to be involved in glutathione metabolic process. Located in peroxisome. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See GTO1 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (796798..797868, complement)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gto1 is located at the peroxisomes in S. cerevisiae, where it is involved in transulfuration of cysteine into homocysteine, and requires a conserved cysteine residue for its biological activity.
Title: A peroxisomal glutathione transferase of Saccharomyces cerevisiae is functionally related to sulfur amino acid metabolism.
act as 1-Cys thiol transferases
Title: Saccharomyces cerevisiae cells have three Omega class glutathione S-transferases acting as 1-Cys thiol transferases.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables glutathione dehydrogenase (ascorbate) activity	IEA Inferred from Electronic Annotation more info
enables glutathione transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glutathione transferase activity	IEA Inferred from Electronic Annotation more info
enables glutathione transferase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in glutathione metabolic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: omega-class glutathione transferase

NP_011670.3

EC 1.8.5.1

EC 2.5.1.18

Omega-class glutathione transferase; induced under oxidative stress; putative peroxisomal localization

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

796798..797868 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181283.3 → NP_011670.3 TPA: omega-class glutathione transferase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011670.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VUT4, P48239

UniProtKB/TrEMBL

G2WEN4, N1P446

Conserved Domains (1) summary

COG0435
Location:1 → 356

ECM4; Glutathionyl-hydroquinone reductase [Energy production and conversion]