Endou endonuclease, polyU-specific [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Endouprovided by MGI
Official Full Name: endonuclease, polyU-specificprovided by MGI
Primary source: MGI:MGI:97746
See related: Ensembl:ENSMUSG00000022468 AllianceGenome:MGI:97746
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pp11r; Tcl-30
Summary: Predicted to enable RNA binding activity; RNA endonuclease activity; and serine-type peptidase activity. Predicted to be involved in female pregnancy; negative regulation of metabolic process; and proteolysis. Predicted to be located in cytoplasm. Is expressed in ileum; labyrinthine zone; and metanephros. Orthologous to human ENDOU (endonuclease, poly(U) specific). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in thymus adult (RPKM 54.3) and lung adult (RPKM 2.5) See more
Orthologs: human all
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Genomic context

Location:: 15 F1; 15 53.7 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (97608896..97629286, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (97711015..97731405, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EndoU is a critical regulator of an RNA-dependent pathway controlling peripheral B cell survival and antigen responsiveness that may contribute to peripheral B cell tolerance.
Title: EndoU is a novel regulator of AICD during peripheral B cell selection.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

General gene information

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Markers

M95545 (e-PCR)
- UniSTS:125006

M95545 (e-PCR)
- UniSTS:160500

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables RNA endonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA endonuclease activity	ISO Inferred from Sequence Orthology more info
enables RNA endonuclease activity	ISS Inferred from Sequence or Structural Similarity more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables polysaccharide binding	IEA Inferred from Electronic Annotation more info
enables scavenger receptor activity	IEA Inferred from Electronic Annotation more info
enables serine-type peptidase activity	ISO Inferred from Sequence Orthology more info
NOT enables serine-type peptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables serine-type peptidase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in female pregnancy	ISS Inferred from Sequence or Structural Similarity more info
involved_in immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of lipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in post-transcriptional gene silencing	IEA Inferred from Electronic Annotation more info
involved_in post-transcriptional gene silencing	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	ISS Inferred from Sequence or Structural Similarity more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: uridylate-specific endoribonuclease

Names: PP11-related protein; T-cell-specific protein 30; placental protein 11 related; placental protein 11-related protein; poly(U)-specific endoribonuclease; protein endoU

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001168693.1 → NP_001162164.1 uridylate-specific endoribonuclease isoform 2 precursor

See identical proteins and their annotated locations for NP_001162164.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains different segments for its 5' UTR and coding region, compared to variant 1. The predicted protein (isoform 2) results from translation initiation at an upstream AUG and has a shorter N-terminus, when it is compared to isoform 1.

Source sequence(s)

AA119943, AC104225, AK132616

Consensus CDS

CCDS49712.1

UniProtKB/Swiss-Prot

Q01084, Q3V188

Related

ENSMUSP00000097820.3, ENSMUST00000100249.10

Conserved Domains (2) summary

pfam01033
Location:22 → 60

Somatomedin_B; Somatomedin B domain

pfam09412
Location:140 → 406

XendoU; Endoribonuclease XendoU
NM_008902.3 → NP_032928.1 uridylate-specific endoribonuclease isoform 1

See identical proteins and their annotated locations for NP_032928.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer protein (isoform 1).

Source sequence(s)

AC104225

Consensus CDS

CCDS27783.1

UniProtKB/Swiss-Prot

Q3V188

Related

ENSMUSP00000023105.4, ENSMUST00000023105.5

Conserved Domains (2) summary

pfam01033
Location:130 → 167

Somatomedin_B; Somatomedin B domain

pfam09412
Location:182 → 448

XendoU; Endoribonuclease XendoU

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

97608896..97629286 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006520618.2 → XP_006520681.1 uridylate-specific endoribonuclease isoform X2

Conserved Domains (2) summary

pfam01033
Location:6 → 44

Somatomedin_B; Somatomedin B domain

pfam09412
Location:124 → 390

XendoU; Endoribonuclease XendoU
XM_006520617.4 → XP_006520680.2 uridylate-specific endoribonuclease isoform X1

Conserved Domains (2) summary

pfam01033
Location:46 → 84

Somatomedin_B; Somatomedin B domain

pfam09412
Location:164 → 430

XendoU; Endoribonuclease XendoU
XM_017316511.1 → XP_017172000.1 uridylate-specific endoribonuclease isoform X3

Conserved Domains (2) summary

pfam01033
Location:34 → 71

Somatomedin_B; Somatomedin B domain

pfam09412
Location:86 → 352

XendoU; Endoribonuclease XendoU