Wtap WT1 associating protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wtapprovided by MGI
Official Full Name: WT1 associating proteinprovided by MGI
Primary source: MGI:MGI:1926395
See related: Ensembl:ENSMUSG00000060475 AllianceGenome:MGI:1926395
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2810408K05Rik; 9430038B09Rik
Summary: Predicted to enable identical protein binding activity. Predicted to be involved in mRNA modification; mRNA processing; and regulation of alternative mRNA splicing, via spliceosome. Located in cytoplasm and nucleoplasm. Part of RNA N6-methyladenosine methyltransferase complex. Is expressed in several structures, including early conceptus; embryo mesoderm; hemolymphoid system gland; hindlimb; and jaw epithelium. Orthologous to human WTAP (WT1 associated protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 10.9), CNS E18 (RPKM 10.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A1; 17 8.73 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (13185686..13211430, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (12966799..12992543, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The role of WTAP in regulating macrophage-mediated osteoimmune responses and tissue regeneration in periodontitis.
Title: The role of WTAP in regulating macrophage-mediated osteoimmune responses and tissue regeneration in periodontitis.
Hepatocyte-specific Wtap deficiency promotes hepatocellular carcinoma by activating GRB2-ERK depending on downregulation of proteasome-related genes.
Title: Hepatocyte-specific Wtap deficiency promotes hepatocellular carcinoma by activating GRB2-ERK depending on downregulation of proteasome-related genes.
WTAP Mediated the N6-methyladenosine Modification of PDK4 to Regulate the Malignant Behaviors of Colorectal Cancer Cells In Vitro and In Vivo.
Title: WTAP Mediated the N6-methyladenosine Modification of PDK4 to Regulate the Malignant Behaviors of Colorectal Cancer Cells In Vitro and In Vivo.
WTAP promotes macrophage recruitment and increases VEGF secretion via N6-methyladenosine modification in corneal neovascularization.
Title: WTAP promotes macrophage recruitment and increases VEGF secretion via N6-methyladenosine modification in corneal neovascularization.
Deficiency of WTAP in islet beta cells results in beta cell failure and diabetes in mice.
Title: Deficiency of WTAP in islet beta cells results in beta cell failure and diabetes in mice.
WTAP contributes to the tumorigenesis of osteosarcoma via modulating ALB in an m6A-dependent manner.
Title: WTAP contributes to the tumorigenesis of osteosarcoma via modulating ALB in an m6A-dependent manner.
WTAP-Mediated m6A RNA Methylation Regulates the Differentiation of Bone Marrow Mesenchymal Stem Cells via the miR-29b-3p/HDAC4 Axis.
Title: WTAP-Mediated m6A RNA Methylation Regulates the Differentiation of Bone Marrow Mesenchymal Stem Cells via the miR-29b-3p/HDAC4 Axis.
WTAP-mediated m[6]A modification modulates bone marrow mesenchymal stem cells differentiation potential and osteoporosis.
Title: WTAP-mediated m(6)A modification modulates bone marrow mesenchymal stem cells differentiation potential and osteoporosis.
N6-methyladenosine (m6A) RNA methylation mediated by methyltransferase complex subunit WTAP regulates amelogenesis.
Title: N6-methyladenosine (m6A) RNA methylation mediated by methyltransferase complex subunit WTAP regulates amelogenesis.
WTAP mediates FOXP3 mRNA stability to promote SMARCE1 expression and augment glycolysis in colon adenocarcinoma.
Title: WTAP mediates FOXP3 mRNA stability to promote SMARCE1 expression and augment glycolysis in colon adenocarcinoma.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Gene trapped (2) 1 citation
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Wtap (e-PCR), detects polymorphism
- UniSTS:498921

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in mRNA modification	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA modification	IEA Inferred from Electronic Annotation more info
involved_in mRNA processing	ISO Inferred from Sequence Orthology more info
involved_in mRNA processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of alternative mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of alternative mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in regulation of alternative mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of RNA N6-methyladenosine methyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
part_of RNA N6-methyladenosine methyltransferase complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: pre-mRNA-splicing regulator WTAP

Names: WT1-associated protein; Wilms tumour 1-associating protein; Wilms' tumour 1-associating protein; female-lethal(2)D homolog; wilms tumor 1-associating protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001113532.1 → NP_001107004.1 pre-mRNA-splicing regulator WTAP isoform b

See identical proteins and their annotated locations for NP_001107004.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks two exons and its transcription extends past a splice site that is used in variant 1, resulting in an immediate translation termination and a different 3' UTR, compared to variant 1. It encodes isoform b which is C-terminal truncated, compared to isoform a. Variants 2 and 3 encode the same isoform b.

Source sequence(s)

AK031965, AK041341, BC093504, BY016042

Consensus CDS

CCDS49949.1

UniProtKB/TrEMBL

F7CCI4

Related

ENSMUSP00000123961.2, ENSMUST00000159986.8

Conserved Domains (1) summary

pfam17098
Location:68 → 150

Wtap; WTAP/Mum2p family
NM_001113533.1 → NP_001107005.1 pre-mRNA-splicing regulator WTAP isoform a

See identical proteins and their annotated locations for NP_001107005.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (a).

Source sequence(s)

AL589878

Consensus CDS

CCDS49950.1

UniProtKB/Swiss-Prot

Q3U120, Q566J5, Q9ER69

UniProtKB/TrEMBL

E0CYH0

Related

ENSMUSP00000007007.8, ENSMUST00000007007.14

Conserved Domains (1) summary

pfam17098
Location:68 → 222

Wtap; WTAP/Mum2p family
NM_001379058.1 → NP_001365987.1 pre-mRNA-splicing regulator WTAP isoform a

Status: VALIDATED

Source sequence(s)

AL589878

UniProtKB/Swiss-Prot

Q3U120, Q566J5, Q9ER69

UniProtKB/TrEMBL

E0CYH0

Related

ENSMUSP00000124205.2, ENSMUST00000159551.8

Conserved Domains (1) summary

pfam17098
Location:68 → 222

Wtap; WTAP/Mum2p family
NM_175394.2 → NP_780603.1 pre-mRNA-splicing regulator WTAP isoform b

See identical proteins and their annotated locations for NP_780603.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) includes an alternate 5' UTR exon and lacks two exons, and its transcription extends past a splice site that is used in variant 1, resulting in an immediate translation termination and a different 3' UTR, compared to variant 1. It encodes isoform b which is C-terminal truncated, compared to isoform a. Variants 2 and 3 encode the same isoform b.

Source sequence(s)

AK031965, AK041341, AK076111

Consensus CDS

CCDS49949.1

UniProtKB/TrEMBL

F7CCI4

Related

ENSMUSP00000124138.2, ENSMUST00000160781.8

Conserved Domains (1) summary

pfam17098
Location:68 → 150

Wtap; WTAP/Mum2p family