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    aroC chorismate synthase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946814, updated on 3-Dec-2024

    Summary

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    Official Symbol
    aroC
    Official Full Name
    chorismate synthase
    Primary source
    ECOCYC:EG10075
    Locus tag
    b2329
    See related
    ASAP:ABE-0007693
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2323
    Summary
    Chorismate synthase acts in the shikimate pathway. [More information is available at EcoCyc: EG10075].
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    Genomic context

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    Sequence:
    NC_000913.3 (2446388..2447473, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene EF-P-Lys34 hydroxylase Neighboring gene putative transporter YfcA Neighboring gene peptidoglycan DD-endopeptidase/peptidoglycan LD-endopeptidase Neighboring gene ribosomal protein L3 N(5)-glutamine methyltransferase Neighboring gene putative endonuclease SmrB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Escherichia coli chorismate synthase: a deuterium kinetic-isotope effect under single-turnover and steady-state conditions shows that a flavin intermediate forms before the C-(6proR)-H bond is cleaved. Bornemann S, et al. Biochem J, 1995 Feb 1. PMID 7848266, Free PMC Article
    2. Studies with substrate and cofactor analogues provide evidence for a radical mechanism in the chorismate synthase reaction. Osborne A, et al. J Biol Chem, 2000 Nov 17. PMID 10956653
    3. A unique reaction in a common pathway: mechanism and function of chorismate synthase in the shikimate pathway. Macheroux P, et al. Planta, 1999 Jan. PMID 9951731
    4. Characterization of candidate live oral Salmonella typhi vaccine strains harboring defined mutations in aroA, aroC, and htrA. Lowe DC, et al. Infect Immun, 1999 Feb. PMID 9916080, Free PMC Article
    5. Studies with flavin analogs provide evidence that a protonated reduced FMN is the substrate-induced transient intermediate in the reaction of Escherichia coli chorismate synthase. Macheroux P, et al. J Biol Chem, 1996 Oct 18. PMID 8824216

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: The overexpression, purification and complete amino acid sequence of chorismate synthase from Escherichia coli K12 and its comparison with the enzyme from Neurospora crassa.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables FMN binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables FMN binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chorismate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chorismate synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chorismate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in aromatic amino acid family biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in aromatic amino acid family biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chorismate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within chorismate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chorismate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    chorismate synthase
    NP_416832.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2446388..2447473 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416832.1 chorismate synthase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416832.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7QQ31, D3H213
      Conserved Domains (1) summary
      PRK05382
      Location:8 → 361
      PRK05382; chorismate synthase; Validated
    Nucleotide Protein
    Heading Accession and Version

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