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    PEP7 phosphatidylinositol-3-phosphate binding protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851923, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PEP7
    Official Full Name
    phosphatidylinositol-3-phosphate binding protein
    Primary source
    SGD:S000002731
    Locus tag
    YDR323C
    See related
    AllianceGenome:SGD:S000002731; FungiDB:YDR323C; VEuPathDB:YDR323C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    VAC1; VPL21; VPS19; VPT19
    Summary
    Enables phosphatidylinositol-3-phosphate binding activity. Involved in several processes, including post-Golgi vesicle-mediated transport; vacuole inheritance; and vesicle docking involved in exocytosis. Located in cytoplasmic side of endosome membrane. Orthologous to human RBSN (rabenosyn, RAB effector). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PEP7 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1112480..1114027, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene mitochondrial 54S ribosomal protein YmL35 Neighboring gene F1F0 ATP synthase subunit e Neighboring gene Utp4p Neighboring gene condensin subunit YCG1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Proteinase mutants of Saccharomyces cerevisiae. Jones EW. Genetics, 1977 Jan. PMID 320092, Free PMC Article
    2. Pep7p provides a novel protein that functions in vesicle-mediated transport between the yeast Golgi and endosome. Webb GC, et al. Mol Biol Cell, 1997 May. PMID 9168472, Free PMC Article
    3. Molecular characterization of VAC1, a gene required for vacuole inheritance and vacuole protein sorting. Weisman LS, et al. J Biol Chem, 1992 Jan 5. PMID 1730622
    4. Mutants of Saccharomyces cerevisiae that block intervacuole vesicular traffic and vacuole division and segregation. Weisman LS, et al. Proc Natl Acad Sci U S A, 1990 Feb. PMID 1689059, Free PMC Article
    5. In vitro reactions of vacuole inheritance in Saccharomyces cerevisiae. Conradt B, et al. J Cell Biol, 1992 Dec. PMID 1334958, Free PMC Article

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-3-phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi to endosome transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in Golgi to endosome transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in Golgi to vacuole transport IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in vacuole inheritance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle docking involved in exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in bounding membrane of organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic side of endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylinositol-3-phosphate binding protein
    NP_010610.3
    • Adaptor protein involved in vesicle-mediated vacuolar protein sorting; multivalent adaptor protein; facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1112480..1114027 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180631.3 → NP_010610.3  TPA: phosphatidylinositol-3-phosphate binding protein [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010610.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSV6, P32609, Q99229
      UniProtKB/TrEMBL
      A6ZYS6, G2WB63, N1P6X4
      Conserved Domains (3) summary
      cd15737
      Location:211 → 293
      FYVE2_Vac1p_like; FYVE domain 2 found in yeast protein VAC1 (Vac1p) and similar proteins
      cd15761
      Location:65 → 141
      FYVE1_Vac1p_like; FYVE-related domain 1 found in yeast protein VAC1 (Vac1p) and similar proteins
      pfam11464
      Location:467 → 502
      Rbsn; Rabenosyn Rab binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32609.2

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