GPR158 G protein-coupled receptor 158 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GPR158provided by HGNC
Official Full Name: G protein-coupled receptor 158provided by HGNC
Primary source: HGNC:HGNC:23689
See related: Ensembl:ENSG00000151025 MIM:614573; AllianceGenome:HGNC:23689
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: mGlyR
Summary: Enables G protein-coupled glycine receptor activity and enzyme activator activity. Involved in G protein-coupled receptor signaling pathway; protein localization to plasma membrane; and regulation of G protein-coupled receptor signaling pathway. Is active in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in brain (RPKM 11.3), adrenal (RPKM 0.9) and 1 other tissue See more
Orthologs: mouse all
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Genomic context

Location:: 10p12.1

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (25175001..25602229)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (25193234..25626794)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (25463930..25891158)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Orphan receptor GPR158 serves as a metabotropic glycine receptor: mGlyR.
Title: Orphan receptor GPR158 serves as a metabotropic glycine receptor: mGlyR.
Cryo-EM structure of human GPR158 receptor coupled to the RGS7-Gbeta5 signaling complex.
Title: Cryo-EM structure of human GPR158 receptor coupled to the RGS7-Gβ5 signaling complex.
Structure of the class C orphan GPCR GPR158 in complex with RGS7-Gbeta5.
Title: Structure of the class C orphan GPCR GPR158 in complex with RGS7-Gβ5.
It findings implicate GPR158 as a homeostatic regulator of intraocular pressure and suggest GPR158 could be a pharmacological target for managing ocular hypertension.
Title: GPR158 in the Visual System: Homeostatic Role in Regulation of Intraocular Pressure.
Elevated GPR158 expression patterns in mucinous ovarian carcinoma patients with unfavorable overall survival.
Title: Immunohistochemical validation of COL3A1, GPR158 and PITHD1 as prognostic biomarkers in early-stage ovarian carcinomas.
Data observed that GPR158 interacted with and stabilized the amount of RGS7-beta5 through a 50-residue region downstream of its transmembrane domain and upstream of the VCPWE motifs. Also, two VCPWE motifs are involved in alphao binding.
Title: Nonclassical Ligand-Independent Regulation of Go Protein by an Orphan Class C G-Protein-Coupled Receptor.
GPR158 is highly upregulated in the prefrontal cortex of human subjects with major depressive disorder. Exposure of mice to chronic stress also increased GPR158 protein levels in the prefrontal cortex in a glucocorticoid-dependent manner.
Title: Orphan receptor GPR158 controls stress-induced depression.
Our results suggest that common ethnic-specific variation in GPR158 may influence energy expenditure (EE) in Pima Indians. rs11014566 nominally associated with measures of EE and adiposity, where the G allele associated with lower 24-h EE, lower Resting Metabolic Rate, higher BMI, and higher percent body fat. But, the association of rs11014566 with BMI did not directionally replicate when assessed in other ethnic groups.
Title: A Genome-Wide Association Study Using a Custom Genotyping Array Identifies Variants in GPR158 Associated With Reduced Energy Expenditure in American Indians.
expression and functional role of orphan receptor GPR158 in prostate cancer growth and progression
Title: Expression and functional role of orphan receptor GPR158 in prostate cancer growth and progression.
Mutation of the NLS abrogates GPR158-mediated enhancement of cell proliferation.
Title: GPR158, an orphan member of G protein-coupled receptor Family C: glucocorticoid-stimulated expression and novel nuclear role.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of antibody response to smallpox vaccine. EBI GWAS Catalog EBI GWAS CatalogPubMed
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-154756 (e-PCR)
- UniSTS:182276

A004G15 (e-PCR)
- UniSTS:50470

RH120575 (e-PCR)
- UniSTS:132408

D10S572 (e-PCR), detects polymorphism
- UniSTS:43133

SHGC-13722 (e-PCR)
- UniSTS:50069

RH121106 (e-PCR)
- UniSTS:134101

D10S572 (e-PCR), detects polymorphism
- UniSTS:27096

SHGC-154563 (e-PCR)
- UniSTS:178140

SHGC-153722 (e-PCR)
- UniSTS:177900

G17491 (e-PCR)
- UniSTS:6396

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled glycine receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables enzyme activator activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane signaling receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in brain development	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in cognition	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of neurotransmitter secretion	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in protein localization to plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synapse organization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in presynaptic membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: metabotropic glycine receptor

Names: probable G-protein coupled receptor 158

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.