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    sgrS [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 4056038, updated on 3-Dec-2024

    Summary

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    Official Symbol
    sgrS
    Primary source
    ECOCYC:G0-9941
    Locus tag
    b4577
    See related
    ASAP:ABE-0285090
    Gene type
    ncRNA
    RNA name
    other
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0071; ryaA
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    Genomic context

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    Sequence:
    NC_000913.3 (77367..77593)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene DNA-binding transcriptional dual regulator SgrR Neighboring gene PtsG glucose transporter inhibitor Neighboring gene sugar exporter SetA Neighboring gene 3-isopropylmalate dehydratase subunit LeuD

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Diverse mechanisms of post-transcriptional repression by the small RNA regulator of glucose-phosphate stress. Bobrovskyy M, et al. Mol Microbiol, 2016 Jan. PMID 26411266, Free PMC Article
    2. Small RNA binding-site multiplicity involved in translational regulation of a polycistronic mRNA. Rice JB, et al. Proc Natl Acad Sci U S A, 2012 Oct 2. PMID 22988087, Free PMC Article
    3. Characterization of homologs of the small RNA SgrS reveals diversity in function. Wadler CS, et al. Nucleic Acids Res, 2009 Sep. PMID 19620214, Free PMC Article
    4. Homologs of the small RNA SgrS are broadly distributed in enteric bacteria but have diverged in size and sequence. Horler RS, et al. Nucleic Acids Res, 2009 Sep. PMID 19531735, Free PMC Article
    5. Analyses of mRNA destabilization and translational inhibition mediated by Hfq-binding small RNAs. Morita T, et al. Methods Enzymol, 2008. PMID 19161852

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Translation inhibition from a distance: The small RNA SgrS silences a ribosomal protein S1-dependent enhancer.
      Title: Translation inhibition from a distance: The small RNA SgrS silences a ribosomal protein S1-dependent enhancer.
    2. SgrS controls glucose-phosphate metabolic stress in a diverse manner.
      Title: Diverse mechanisms of post-transcriptional repression by the small RNA regulator of glucose-phosphate stress.
    3. SgrS Base Pairs with Sequences in the manX-manY Intergenic Region to Regulate manY Translation.
      Title: Small RNA binding-site multiplicity involved in translational regulation of a polycistronic mRNA.
    4. SgrS 168-181 is a minimal base-pairing region for translational inhibition of ptsG mRNA.
      Title: A minimal base-pairing region of a bacterial small RNA SgrS required for translational repression of ptsG mRNA.
    5. These data suggest that SgrS represents a previously unrecognized paradigm for small RNA (sRNA) regulators as a bifunctional RNA that encodes physiologically redundant but mechanistically distinct functions contributing to the same stress response.
      Title: A dual function for a bacterial small RNA: SgrS performs base pairing-dependent regulation and encodes a functional polypeptide.
    6. function and regulation of expression of sgrS; results suggest that under conditions of glucose phosphate accumulation, SgrR activates SgrS synthesis, causing degradation of ptsG mRNA
      Title: Involvement of a novel transcriptional activator and small RNA in post-transcriptional regulation of the glucose phosphoenolpyruvate phosphotransferase system.
    Submit: New GeneRIF Correction

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