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    gnsA putative phosphatidylethanolamine synthesis regulator GnsA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 1450249, updated on 3-Dec-2024

    Summary

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    Official Symbol
    gnsA
    Official Full Name
    putative phosphatidylethanolamine synthesis regulator GnsA
    Primary source
    ECOCYC:G0-9662
    Locus tag
    b4517
    See related
    ASAP:ABE-0285038
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0982; sfa; yccL
    Summary
    [More information is available at EcoGene: EG13233]. GnsA was isolated as a multicopy suppressor of a cold-sensitive secG mutant . [More information is available at EcoCyc: G0-9662].
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    Genomic context

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    Sequence:
    NC_000913.3 (1052067..1052240)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene cold shock protein CspG Neighboring gene protein YmcF Neighboring gene protein YmcE Neighboring gene putative electron transport protein YccM Neighboring gene sensor histidine kinase TorS

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of GnsA from Escherichia coli. Wei Y, et al. Biochem Biophys Res Commun, 2015 Jun 19. PMID 25839658
    2. Overexpression of gnsA, a multicopy suppressor of the secG null mutation, increases acidic phospholipid contents by inhibiting phosphatidylethanolamine synthesis at low temperatures. Sugai R, et al. J Bacteriol, 2004 Sep. PMID 15317805, Free PMC Article
    3. Increased unsaturated fatty acid production associated with a suppressor of the fabA6(Ts) mutation in Escherichia coli. Rock CO, et al. J Bacteriol, 1996 Sep. PMID 8808925, Free PMC Article
    4. Overexpression of yccL (gnsA) and ydfY (gnsB) increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation of Escherichia coli. Sugai R, et al. J Bacteriol, 2001 Oct. PMID 11544213, Free PMC Article
    5. Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification. Liu F, et al. Nat Commun, 2017 May 19. PMID 28524877, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    putative phosphatidylethanolamine synthesis regulator GnsA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1052067..1052240
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_588446.1 putative phosphatidylethanolamine synthesis regulator GnsA [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for YP_588446.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A3L9II02
      Conserved Domains (1) summary
      pfam08178
      Location:1 → 54
      GnsAB_toxin; GnsA/GnsB toxin of bacterial toxin-antitoxin system
    Nucleotide Protein
    Heading Accession and Version

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