U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    purE N(5)-carboxyaminoimidazole ribonucleotide mutase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 949031, updated on 3-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    purE
    Official Full Name
    N(5)-carboxyaminoimidazole ribonucleotide mutase
    Primary source
    ECOCYC:EG10793
    Locus tag
    b0523
    See related
    ASAP:ABE-0001796
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ade; ade(f); ade3; ECK0516; Pur2
    Summary
    PurE was previously thought to be the catalytic subunit of phosphoribosylaminoimidazole carboxylase, with ATPase subunit PurK (Tiedeman, 1989). [More information is available at EcoGene: EG10793]. PurK and PurE were previously thought to be two subunits of AIR carboxylase , though more recent studies have shown the enzymes to be subunits of a distinct carboxylase and mutase, respectively . [More information is available at EcoCyc: EG10793].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (552591..553100, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF1116 domain-containing protein YlbE Neighboring gene DUF2877 domain-containing protein YlbF Neighboring gene putative carbamate kinase Neighboring gene 5-(carboxyamino)imidazole ribonucleotide synthase Neighboring gene UDP-2,3-diacylglucosamine diphosphatase Neighboring gene peptidyl-prolyl cis-trans isomerase B

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Molecular cloning and characterization of the purE operon of Escherichia coli. Kamholz J, et al. Gene, 1986. PMID 3021590
    2. A DNA-binding protein with specificity for pur genes in Escherichia coli. Koduri RK, et al. J Biol Chem, 1980 Oct 25. PMID 7000760
    3. Reactions catalyzed by 5-aminoimidazole ribonucleotide carboxylases from Escherichia coli and Gallus gallus: a case for divergent catalytic mechanisms. Firestine SM, et al. Biochemistry, 1994 Oct 4. PMID 7918411
    4. N5-carboxyaminoimidazole ribonucleotide: evidence for a new intermediate and two new enzymatic activities in the de novo purine biosynthetic pathway of Escherichia coli. Mueller EJ, et al. Biochemistry, 1994 Mar 1. PMID 8117684
    5. Purification and characterization of the purE, purK, and purC gene products: identification of a previously unrecognized energy requirement in the purine biosynthetic pathway. Meyer E, et al. Biochemistry, 1992 Jun 2. PMID 1534690

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: Purification and characterization of the purE, purK, and purC gene products: identification of a previously unrecognized energy requirement in the purine biosynthetic pathway.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 5-(carboxyamino)imidazole ribonucleotide mutase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 5-(carboxyamino)imidazole ribonucleotide mutase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' IMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in purine nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    N(5)-carboxyaminoimidazole ribonucleotide mutase
    NP_415056.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      552591..553100 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415056.1 N(5)-carboxyaminoimidazole ribonucleotide mutase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415056.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376MCF8
      Conserved Domains (1) summary
      COG0041
      Location:6 → 169
      PurE; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.