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    TMS1 Tms1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851682, updated on 27-Dec-2024

    Summary

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    Official Symbol
    TMS1
    Official Full Name
    Tms1p
    Primary source
    SGD:S000002512
    Locus tag
    YDR105C
    See related
    AllianceGenome:SGD:S000002512; FungiDB:YDR105C; VEuPathDB:YDR105C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Located in fungal-type vacuole membrane and membrane raft. Is active in endosome. Orthologous to several human genes including SERINC1 (serine incorporator 1) and SERINC3 (serine incorporator 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See TMS1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (665349..666770, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Ste5p Neighboring gene Spo71p Neighboring gene Arp10p Neighboring gene tRNA-Ile

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Interaction between ESCRT-III proteins and the yeast SERINC homolog Tms1. Kölling R. Genetics, 2024 Oct 7. PMID 39271159
    2. Identification of a ubiquitous family of membrane proteins and their expression in mouse brain. Grossman TR, et al. J Exp Biol, 2000 Feb. PMID 10637174
    3. Two-hybrid-based analysis of protein-protein interactions of the yeast multidrug resistance protein, Pdr5p. Subba Rao G, et al. Funct Integr Genomics, 2002 Apr. PMID 11957110
    4. Direct imaging reveals stable, micrometer-scale lipid domains that segregate proteins in live cells. Toulmay A, et al. J Cell Biol, 2013 Jul 8. PMID 23836928, Free PMC Article
    5. Analysis of the TORC1 interactome reveals a spatially distinct function of TORC1 in mRNP complexes. Chang Y, et al. J Cell Biol, 2021 Apr 5. PMID 33566094, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fungal-type vacuole membrane HDA PubMed 
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Tms1p
    NP_010390.3
    • Putative scramblase involved in ESCRT-III-dependent membrane remodeling; localizes to the endosome and vacuolar membrane; predicted to contain eleven transmembrane helices; synergistic defect with VPS55 and VPS68 in the sorting of MVB cargo proteins; interacts physically with ESCRT-III subunits; conserved member of the SERINC (serine incorporator) protein family

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      665349..666770 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180413.3 → NP_010390.3  TPA: Tms1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010390.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VS91, Q12116
      UniProtKB/TrEMBL
      A6ZY68, B3LGH0, B5VG03, C7GQK0, G2WAK8, N1P4Q1
      Conserved Domains (1) summary
      pfam03348
      Location:12 → 467
      Serinc; Serine incorporator (Serinc)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12116.1

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