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    RPN5 proteasome regulatory particle lid subunit RPN5 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851408, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RPN5
    Official Full Name
    proteasome regulatory particle lid subunit RPN5
    Primary source
    SGD:S000002306
    Locus tag
    YDL147W
    See related
    AllianceGenome:SGD:S000002306; FungiDB:YDL147W; VEuPathDB:YDL147W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    NAS5
    Summary
    Involved in protein deneddylation. Located in proteasome storage granule. Part of COP9 signalosome and proteasome regulatory particle, lid subcomplex. Used to study cancer. Orthologous to human PSMD12 (proteasome 26S subunit, non-ATPase 12). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RPN5 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (190924..192261)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene autophagy protein ATG9 Neighboring gene snoRNA-binding rRNA-processing protein NOP14 Neighboring gene Ldb17p Neighboring gene coatomer subunit alpha

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NMR (1)H, (13)C, (15)N backbone and side chain resonance assignment of the N-terminal domain of yeast proteasome lid subunit Rpn5. Zhang W, et al. Biomol NMR Assign, 2019 Apr. PMID 30229448
    2. Solution structure of the N-terminal domain of proteasome lid subunit Rpn5. Zhang W, et al. Biochem Biophys Res Commun, 2018 Sep 26. PMID 30177392
    3. The assembly pathway of the 19S regulatory particle of the yeast 26S proteasome. Isono E, et al. Mol Biol Cell, 2007 Feb. PMID 17135287, Free PMC Article
    4. Solution structure of yeast Rpn9: insights into proteasome lid assembly. Hu Y, et al. J Biol Chem, 2015 Mar 13. PMID 25631053, Free PMC Article
    5. Small epitope-linker modules for PCR-based C-terminal tagging in Saccharomyces cerevisiae. Funakoshi M, et al. Yeast, 2009 Mar. PMID 19243080, Free PMC Article

    See all (137) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. analysis of proteasome lid subunit Rpn5 solution structure
      Title: Solution structure of the N-terminal domain of proteasome lid subunit Rpn5.
    2. Data demonstrate that, in Saccharomyces cerevisiae, Rpn5 plays dual roles by stabilizing 26S proteasome and COP9 signalosome structures independently.
      Title: Dual function of Rpn5 in two PCI complexes, the 26S proteasome and COP9 signalosome.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein deneddylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of COP9 signalosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome regulatory particle, lid subcomplex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome regulatory particle, lid subcomplex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome regulatory particle, lid subcomplex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in proteasome storage granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    proteasome regulatory particle lid subunit RPN5
    NP_010134.1
    • Subunit of the CSN and 26S proteasome lid complexes; similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p; Rpn5p is an essential protein; the COP9 signalosome is also known as the CSN

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      190924..192261
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180207.1 → NP_010134.1  TPA: proteasome regulatory particle lid subunit RPN5 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010134.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRK1, Q12250
      UniProtKB/TrEMBL
      A6ZXI0, B5VFC1, C7GKZ8, C8Z6F5, G2WC14, N1P956
      Conserved Domains (1) summary
      COG5071
      Location:5 → 445
      RPN5; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12250.3

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