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    uncharacterized protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850387, updated on 27-Dec-2024

    Summary

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    Official Full Name
    uncharacterized protein
    Primary source
    SGD:S000000617
    Locus tag
    YCR023C
    See related
    AllianceGenome:SGD:S000000617; FungiDB:YCR023C; VEuPathDB:YCR023C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable chloride channel activity. Predicted to be involved in chloride transmembrane transport. Located in fungal-type vacuole membrane. Used to study neuronal ceroid lipofuscinosis. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (158538..160373, complement)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene Hsp30p Neighboring gene uncharacterized protein Neighboring gene asparagine--tRNA ligase SLM5 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The complete sequence of K3B, a 7.9 kb fragment between PGK1 and CRY1 on chromosome III, reveals the presence of seven open reading frames. Bolle PA, et al. Yeast, 1992 Mar. PMID 1574926
    2. Localization and function of the yeast multidrug transporter Tpo1p. Albertsen M, et al. J Biol Chem, 2003 Apr 11. PMID 12562762
    3. The yeast vacuolar membrane proteome. Wiederhold E, et al. Mol Cell Proteomics, 2009 Feb. PMID 19001347
    4. Regulation of septin dynamics by the Saccharomyces cerevisiae lysine acetyltransferase NuA4. Mitchell L, et al. PLoS One, 2011. PMID 21984913, Free PMC Article
    5. The complete DNA sequence of yeast chromosome III. Oliver SG, et al. Nature, 1992 May 7. PMID 1574125

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables chloride channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in chloride transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chloride transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of chloride channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    NP_009952.2
    • Vacuolar membrane hypothetical protein; homolog of human CLN7 which is an organellar chloride channel regulating lysosomal function; targeted to vacuole via AP-3 pathway; member of multidrug resistance family; not an essential gene

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      158538..160373 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178737.1 → NP_009952.2  TPA: uncharacterized protein YCR023C [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009952.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VR32, P25351, Q8NKJ7
      UniProtKB/TrEMBL
      A6ZTK4, B3LU94, C7GW73, C8Z4B3, N1PAQ2
      Conserved Domains (1) summary
      cd17330
      Location:23 → 564
      MFS_SLC46_TetA_like; Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25351.2

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