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    LSM8 U4/U6-U5 snRNP complex subunit LSM8 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853479, updated on 9-Dec-2024

    Summary

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    Official Symbol
    LSM8
    Official Full Name
    U4/U6-U5 snRNP complex subunit LSM8
    Primary source
    SGD:S000003783
    Locus tag
    YJR022W
    See related
    AllianceGenome:SGD:S000003783; FungiDB:YJR022W; VEuPathDB:YJR022W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to RNA binding activity. Involved in mRNA splicing, via spliceosome. Located in nucleolus. Part of U4/U6 x U5 tri-snRNP complex and U6 snRNP. Orthologous to human LSM8 (LSM8 homolog, U6 small nuclear RNA associated). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See LSM8 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (469784..470113)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene palmitoyl-CoA hydrolase Neighboring gene Rec107p Neighboring gene methylthioribulose 1-phosphate dehydratase MDE1 Neighboring gene 3-hydroxyanthranilate 3,4-dioxygenase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A role for the yeast La protein in U6 snRNP assembly: evidence that the La protein is a molecular chaperone for RNA polymerase III transcripts. Pannone BK, et al. EMBO J, 1998 Dec 15. PMID 9857199, Free PMC Article
    2. Analysis of Lsm1p and Lsm8p domains in the cellular localization of Lsm complexes in budding yeast. Reijns MA, et al. FEBS J, 2009 Jul. PMID 19490016, Free PMC Article
    3. An intrinsically disordered C terminus allows the La protein to assist the biogenesis of diverse noncoding RNA precursors. Kucera NJ, et al. Proc Natl Acad Sci U S A, 2011 Jan 25. PMID 21212361, Free PMC Article
    4. Rapid isolation and single-molecule analysis of ribonucleoproteins from cell lysate by SNAP-SiMPull. Rodgers ML, et al. RNA, 2015 May. PMID 25805862, Free PMC Article
    5. Characterization of U6 snRNA-protein interactions. Vidal VP, et al. RNA, 1999 Nov. PMID 10580475, Free PMC Article

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results describe a range of mutant and hybrid Lsm1 and Lsm8 proteins, shedding light on the relative importance of their various domains in determining their localization and ability to support growth.
      Title: Analysis of Lsm1p and Lsm8p domains in the cellular localization of Lsm complexes in budding yeast.
    2. Lsm2-8p complex normally targets nuclear RNA substrates for decapping
      Title: Nuclear pre-mRNA decapping and 5' degradation in yeast require the Lsm2-8p complex.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of U4/U6 x U5 tri-snRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U4/U6 x U5 tri-snRNP complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U4/U6 x U5 tri-snRNP complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of U6 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U6 snRNP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U6 snRNP IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of precatalytic spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    U4/U6-U5 snRNP complex subunit LSM8
    NP_012556.2
    • Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA, pre-snoRNA, and pre-rRNA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      469784..470113
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181680.1 → NP_012556.2  TPA: U4/U6-U5 snRNP complex subunit LSM8 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012556.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWJ6, P47093
      UniProtKB/TrEMBL
      A6ZPY8, B3LQB8, C7GWK9, D3UF83, G2WH33
      Conserved Domains (1) summary
      cd01727
      Location:2 → 85
      LSm8; Like-Sm protein 8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47093.2

    Gene LinkOut

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