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    LPX2 Lpx2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853816, updated on 9-Dec-2024

    Summary

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    Official Symbol
    LPX2
    Official Full Name
    Lpx2p
    Primary source
    SGD:S000001533
    Locus tag
    YKL050C
    See related
    AllianceGenome:SGD:S000001533; FungiDB:YKL050C; VEuPathDB:YKL050C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to be involved in eisosome assembly. Located in peroxisome. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See LPX2 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (342852..345620, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Ask1p Neighboring gene Sfk1p Neighboring gene centromeric DNA-binding histone H3-like protein CSE4 Neighboring gene serine/threonine protein kinase ELM1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Exploiting spore-autonomous fluorescent protein expression to quantify meiotic chromosome behaviors in Saccharomyces cerevisiae. Thacker D, et al. Genetics, 2011 Oct. PMID 21840861, Free PMC Article
    2. The function and properties of the Azf1 transcriptional regulator change with growth conditions in Saccharomyces cerevisiae. Slattery MG, et al. Eukaryot Cell, 2006 Feb. PMID 16467472, Free PMC Article
    3. Genome-wide surveys for phosphorylation-dependent substrates of SCF ubiquitin ligases. Tang X, et al. Methods Enzymol, 2005. PMID 16338374
    4. Mass-murdering: deletion of twenty-three ORFs from Saccharomyces cerevisiae chromosome XI reveals five genes essential for growth and three genes conferring detectable mutant phenotype. Wysocki R, et al. Gene, 1999 Mar 18. PMID 10095102
    5. Systematic multi-level analysis of an organelle proteome reveals new peroxisomal functions. Yifrach E, et al. Mol Syst Biol, 2022 Sep. PMID 36164978, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in eisosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Lpx2p
    NP_012874.1
    • Peroxisomal matrix-localized lipase; target of SCFCdc4 ubiquitin ligase complex; peroxisomal, nuclear and cytosolic localization is dependent on the presence of oleate; transcription is regulated by Azf1p; LPX2 has a paralog, EIS1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      342852..345620 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179616.1 → NP_012874.1  TPA: Lpx2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012874.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXN7, P35736
      UniProtKB/TrEMBL
      B3LR39, N1P0M6
      Conserved Domains (1) summary
      pfam12757
      Location:347 → 466
      Eisosome1; Eisosome protein 1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35736.1

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