U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ATG34 Atg34p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854071, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ATG34
    Official Full Name
    Atg34p
    Primary source
    SGD:S000005443
    Locus tag
    YOL083W
    See related
    AllianceGenome:SGD:S000005443; FungiDB:YOL083W; VEuPathDB:YOL083W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein-macromolecule adaptor activity. Involved in several processes, including macroautophagy; protein targeting to vacuole involved in autophagy; and protein-containing complex localization. Located in cytosol. Part of Cvt complex. [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ATG34 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (165714..166952)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Phm7p Neighboring gene Atg19p Neighboring gene Ras GTPase activating protein IRA2

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Selective transport of alpha-mannosidase by autophagic pathways: structural basis for cargo recognition by Atg19 and Atg34. Watanabe Y, et al. J Biol Chem, 2010 Sep 24. PMID 20659891, Free PMC Article
    2. Hrr25 phosphorylates the autophagic receptor Atg34 to promote vacuolar transport of α-mannosidase under nitrogen starvation conditions. Mochida K, et al. FEBS Lett, 2014 Nov 3. PMID 25281559
    3. Structural Biology of the Cvt Pathway. Yamasaki A, et al. J Mol Biol, 2017 Feb 17. PMID 28077284
    4. Cargo binding to Atg19 unmasks additional Atg8 binding sites to mediate membrane-cargo apposition during selective autophagy. Sawa-Makarska J, et al. Nat Cell Biol, 2014 May. PMID 24705553, Free PMC Article
    5. Hrr25 kinase promotes selective autophagy by phosphorylating the cargo receptor Atg19. Pfaffenwimmer T, et al. EMBO Rep, 2014 Aug. PMID 24968893, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hrr25 as the kinase that phosphorylates to promote vacuolar transport of alpha-mannosidase Atg34
      Title: Hrr25 phosphorylates the autophagic receptor Atg34 to promote vacuolar transport of α-mannosidase under nitrogen starvation conditions.
    2. Atg34p and Atg19p have similar domain structures and are important for Ams1p transport during autophagy.
      Title: Selective transport of alpha-mannosidase by autophagic pathways: identification of a novel receptor, Atg34p.
    3. Selective transport of alpha-mannosidase by autophagic pathways: structural basis for cargo recognition by Atg19 and Atg34.
      Title: Selective transport of alpha-mannosidase by autophagic pathways: structural basis for cargo recognition by Atg19 and Atg34.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in macroautophagy IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein targeting to vacuole involved in autophagy IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein-containing complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein-containing complex localization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Cvt complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in phagophore assembly site membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Atg34p
    NP_014558.1
    • Receptor protein involved in selective autophagy during starvation; specifically involved in the transport of cargo protein alpha-mannosidase (Ams1p); Atg19p paralog

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      165714..166952
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183337.1 → NP_014558.1  TPA: Atg34p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014558.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1Y5, Q12292
      UniProtKB/TrEMBL
      C7GK47, N1NZ43
      Conserved Domains (1) summary
      pfam12744
      Location:164 → 412
      ATG19_autophagy; Autophagy protein Atg19, Atg8-binding
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12292.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools