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    HAT1 histone acetyltransferase catalytic subunit HAT1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856106, updated on 9-Dec-2024

    Summary

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    Official Symbol
    HAT1
    Official Full Name
    histone acetyltransferase catalytic subunit HAT1
    Primary source
    SGD:S000005922
    Locus tag
    YPL001W
    See related
    AllianceGenome:SGD:S000005922; FungiDB:YPL001W; VEuPathDB:YPL001W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    KAT1
    Summary
    Enables chromatin binding activity and histone acetyltransferase activity. Involved in double-strand break repair and subtelomeric heterochromatin formation. Located in cytoplasm and nucleus. Part of histone acetyltransferase complex. Orthologous to human HAT1 (histone acetyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See HAT1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (554605..555729)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Ula1p Neighboring gene ESCRT-II subunit protein SNF8 Neighboring gene citrate (Si)-synthase CIT3 Neighboring gene putative 2-methylcitrate dehydratase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of a gene encoding a yeast histone H4 acetyltransferase. Kleff S, et al. J Biol Chem, 1995 Oct 20. PMID 7559580
    2. Histone H3 and the histone acetyltransferase Hat1p contribute to DNA double-strand break repair. Qin S, et al. Mol Cell Biol, 2002 Dec. PMID 12417736, Free PMC Article
    3. Type B histone acetyltransferase Hat1p participates in telomeric silencing. Kelly TJ, et al. Mol Cell Biol, 2000 Oct. PMID 10982821, Free PMC Article
    4. Effects of acetylation of histone H4 at lysines 8 and 16 on activity of the Hat1 histone acetyltransferase. Makowski AM, et al. J Biol Chem, 2001 Nov 23. PMID 11585814
    5. Crystal structure of yeast Esa1 suggests a unified mechanism for catalysis and substrate binding by histone acetyltransferases. Yan Y, et al. Mol Cell, 2000 Nov. PMID 11106757

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the NuB4/HAT-B complex, containing the conserved type B histone acetyltransferase Hat1, was found to promote histone turnover.
      Title: A barcode screen for epigenetic regulators reveals a role for the NuB4/HAT-B histone acetyltransferase complex in histone turnover.
    2. analysis of the role of the nuclear HAT1 complex (NuB4) components in DNA repair-linked chromatin reassembly
      Title: Nuclear Hat1p complex (NuB4) components participate in DNA repair-linked chromatin reassembly.
    3. analysis of Hat1p (Kat1p) catalytic activity and subcellular localization in telomeric silencing
      Title: Involvement of Hat1p (Kat1p) catalytic activity and subcellular localization in telomeric silencing.
    4. Site specificity of histone acetyltransferase B complex in vivo is reported.
      Title: Site specificity of yeast histone acetyltransferase B complex in vivo.
    5. The participation of a distinct Hat1p/Hat2p sub-complex suggests a linkage of histone H4 modification with ORC-dependent DNA replication
      Title: Association with the origin recognition complex suggests a novel role for histone acetyltransferase Hat1p/Hat2p.
    6. Hat1p plays a direct role in DNA damage repair and is responsible for specific changes in histone modification that occur during the course of recombinational DNA repair.
      Title: Recruitment of the type B histone acetyltransferase Hat1p to chromatin is linked to DNA double-strand breaks.
    7. the role of Hat1 in DNA damage repair is evolutionarily conserved, the ability of H3 acetylation to compensate for Hat1 deletion appears to be more variable
      Title: Properties of the type B histone acetyltransferase Hat1: H4 tail interaction, site preference, and involvement in DNA repair.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H2AK5 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AK9 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BK12 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BK5 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K122 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K14 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K18 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K23 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K27 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K36 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K4 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K56 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K9 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4 acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H4K12 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4K16 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4K5 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4K8 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone acetyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables histone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide-lysine-N-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in subtelomeric heterochromatin formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in subtelomeric heterochromatin formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of histone acetyltransferase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    histone acetyltransferase catalytic subunit HAT1
    NP_015324.1
    • Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex; uses the cofactor acetyl coenzyme A to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      554605..555729
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183815.1 → NP_015324.1  TPA: histone acetyltransferase catalytic subunit HAT1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015324.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W411, Q12341, Q6Q5I5
      UniProtKB/TrEMBL
      B5VTG0, C7GV46, C8ZJ25, N1NW00
      Conserved Domains (2) summary
      pfam00583
      Location:166 → 260
      Acetyltransf_1; Acetyltransferase (GNAT) family
      pfam10394
      Location:11 → 162
      Hat1_N; Histone acetyl transferase HAT1 N-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12341.1

    Gene LinkOut

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