TIF6 translation initiation factor 6 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: TIF6
Official Full Name: translation initiation factor 6
Primary source: SGD:S000006220
Locus tag: YPR016C
See related: AllianceGenome:SGD:S000006220; FungiDB:YPR016C; VEuPathDB:YPR016C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: CDC95
Summary: Enables ribosomal large subunit binding activity. Involved in ribosome biogenesis. Located in cytoplasm and nucleolus. Part of preribosome, large subunit precursor. Used to study Shwachman-Diamond syndrome. Orthologous to human EIF6 (eukaryotic translation initiation factor 6). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See TIF6 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (592332..593069, complement)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hrr25p-mediated phosphorylation of Tif6p plays a critical role in the biogenesis of 60 S ribosomal subunits in yeast cells.
Title: The Saccharomyces cerevisiae 60 S ribosome biogenesis factor Tif6p is regulated by Hrr25p-mediated phosphorylation.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ribosomal large subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables ribosomal large subunit binding	IDA Inferred from Direct Assay more info	PubMed
enables ribosomal large subunit binding	IEA Inferred from Electronic Annotation more info
enables ribosome binding	IEA Inferred from Electronic Annotation more info
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in assembly of large subunit precursor of preribosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in assembly of large subunit precursor of preribosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytosolic ribosome assembly	IEA Inferred from Electronic Annotation more info
involved_in maturation of 5.8S rRNA	IBA Inferred from Biological aspect of Ancestor more info
involved_in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maturation of LSU-rRNA	IBA Inferred from Biological aspect of Ancestor more info
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rRNA processing	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ribosomal large subunit biogenesis	IEA Inferred from Electronic Annotation more info
involved_in ribosomal large subunit biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribosomal subunit export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosomal subunit export from nucleus	IEA Inferred from Electronic Annotation more info
involved_in ribosomal subunit export from nucleus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ribosome biogenesis	IEA Inferred from Electronic Annotation more info
involved_in translation	IEA Inferred from Electronic Annotation more info
involved_in translational initiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of preribosome, large subunit precursor	HDA more info	PubMed
part_of preribosome, large subunit precursor	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: translation initiation factor 6

NP_015341.1

Constituent of 66S pre-ribosomal particles; has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

592332..593069 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001184113.1 → NP_015341.1 TPA: translation initiation factor 6 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015341.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W426, Q12522

UniProtKB/TrEMBL

A6ZWQ9, B3LL77, B5VTH5, C7GQC2, C8ZJ40, G2WPJ4, N1P200

Conserved Domains (1) summary

PTZ00136
Location:1 → 245

PTZ00136; eukaryotic translation initiation factor 6-like protein; Provisional