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    ZNF234 zinc finger protein 234 [ Homo sapiens (human) ]

    Gene ID: 10780, updated on 27-Nov-2024

    Summary

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    Official Symbol
    ZNF234provided by HGNC
    Official Full Name
    zinc finger protein 234provided by HGNC
    Primary source
    HGNC:HGNC:13027
    See related
    Ensembl:ENSG00000263002 MIM:604750; AllianceGenome:HGNC:13027
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HZF4; ZNF269
    Summary
    Predicted to enable DNA binding activity and metal ion binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in spleen (RPKM 2.1), thyroid (RPKM 2.0) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF234 in Genome Data Viewer
    Location:
    19q13.31
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (44141554..44160313)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (46964407..46983173)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44645707..44664466)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 224 Neighboring gene ZNF225 and ZNF224 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:44617263-44617613 Neighboring gene zinc finger protein 225 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:44645889-44646479 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14756 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14757 Neighboring gene zinc finger protein 226 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14758 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14759 Neighboring gene zinc finger protein 227 Neighboring gene uncharacterized LOC124904726

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937. Abrink M, et al. DNA Cell Biol, 1995 Feb. PMID 7865130
    2. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. Shannon M, et al. Genome Res, 2003 Jun. PMID 12743021, Free PMC Article
    3. A GO catalogue of human DNA-binding transcription factors. Lovering RC, et al. Biochim Biophys Acta Gene Regul Mech, 2021 Nov-Dec. PMID 34673265
    4. Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways. Wang J, et al. J Proteome Res, 2008 Sep. PMID 18624398
    5. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. Bett JS, et al. Biochem J, 2013 Apr 15. PMID 23398456, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 234
    Names
    C2-H2 type zinc finger protein
    Homo sapiens zinc finger 234
    zinc finger protein 234, partial sequence
    zinc finger protein 269
    zinc finger protein 4
    zinc finger protein HZF4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001144824.2 → NP_001138296.1  zinc finger protein 234

      See identical proteins and their annotated locations for NP_001138296.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC021092, AC138470, AK314064
      Consensus CDS
      CCDS46101.1
      UniProtKB/Swiss-Prot
      A8K1C8, Q14588, Q96IR4, Q9NS45, Q9NYT7
      Related
      ENSP00000465011.1, ENST00000592437.5
      Conserved Domains (6) summary
      smart00349
      Location:8 → 65
      KRAB; krueppel associated box
      COG5048
      Location:258 → 672
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:486 → 506
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:204 → 226
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:8 → 47
      KRAB; KRAB box
      pfam13465
      Location:639 → 662
      zf-H2C2_2; Zinc-finger double domain

    2. NM_006630.3 → NP_006621.1  zinc finger protein 234

      See identical proteins and their annotated locations for NP_006621.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC021092, AC138470, AK289843, AK314064
      Consensus CDS
      CCDS46101.1
      UniProtKB/Swiss-Prot
      A8K1C8, Q14588, Q96IR4, Q9NS45, Q9NYT7
      Related
      ENSP00000400878.1, ENST00000426739.7
      Conserved Domains (6) summary
      smart00349
      Location:8 → 65
      KRAB; krueppel associated box
      COG5048
      Location:258 → 672
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:486 → 506
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:204 → 226
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:8 → 47
      KRAB; KRAB box
      pfam13465
      Location:639 → 662
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      44141554..44160313
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438061.1 → XP_047294017.1  zinc finger protein 234 isoform X2

    2. XM_006722974.4 → XP_006723037.1  zinc finger protein 234 isoform X1

      See identical proteins and their annotated locations for XP_006723037.1

      UniProtKB/Swiss-Prot
      A8K1C8, Q14588, Q96IR4, Q9NS45, Q9NYT7
      Conserved Domains (6) summary
      smart00349
      Location:8 → 65
      KRAB; krueppel associated box
      COG5048
      Location:258 → 672
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:486 → 506
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:204 → 226
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:8 → 47
      KRAB; KRAB box
      pfam13465
      Location:639 → 662
      zf-H2C2_2; Zinc-finger double domain

    3. XM_047438063.1 → XP_047294019.1  zinc finger protein 234 isoform X3

    4. XM_017026149.2 → XP_016881638.1  zinc finger protein 234 isoform X1

      UniProtKB/Swiss-Prot
      A8K1C8, Q14588, Q96IR4, Q9NS45, Q9NYT7
      Conserved Domains (6) summary
      smart00349
      Location:8 → 65
      KRAB; krueppel associated box
      COG5048
      Location:258 → 672
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:486 → 506
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:204 → 226
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:8 → 47
      KRAB; KRAB box
      pfam13465
      Location:639 → 662
      zf-H2C2_2; Zinc-finger double domain

    5. XM_017026150.2 → XP_016881639.1  zinc finger protein 234 isoform X2

      Conserved Domains (6) summary
      smart00349
      Location:8 → 63
      KRAB; krueppel associated box
      COG5048
      Location:246 → 660
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:474 → 494
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:192 → 214
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:8 → 47
      KRAB; KRAB box
      pfam13465
      Location:627 → 650
      zf-H2C2_2; Zinc-finger double domain

    6. XM_017026151.2 → XP_016881640.1  zinc finger protein 234 isoform X3

    7. XM_047438060.1 → XP_047294016.1  zinc finger protein 234 isoform X2

    8. XM_047438062.1 → XP_047294018.1  zinc finger protein 234 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      46964407..46983173
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054319544.1 → XP_054175519.1  zinc finger protein 234 isoform X1

    2. XM_054319547.1 → XP_054175522.1  zinc finger protein 234 isoform X2

    3. XM_054319549.1 → XP_054175524.1  zinc finger protein 234 isoform X3

    4. XM_054319546.1 → XP_054175521.1  zinc finger protein 234 isoform X2

    5. XM_054319548.1 → XP_054175523.1  zinc finger protein 234 isoform X3

    6. XM_054319545.1 → XP_054175520.1  zinc finger protein 234 isoform X1

    7. XM_054319550.1 → XP_054175525.1  zinc finger protein 234 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14588.3 GenPept UniProtKB/Swiss-Prot:Q14588

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