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    GPR160 G protein-coupled receptor 160 [ Homo sapiens (human) ]

    Gene ID: 26996, updated on 27-Nov-2024

    Summary

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    Official Symbol
    GPR160provided by HGNC
    Official Full Name
    G protein-coupled receptor 160provided by HGNC
    Primary source
    HGNC:HGNC:23693
    See related
    Ensembl:ENSG00000173890 AllianceGenome:HGNC:23693
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GPCR1; GPCR150
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Located in plasma membrane. Part of receptor complex. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in small intestine (RPKM 20.7), duodenum (RPKM 16.2) and 15 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GPR160 in Genome Data Viewer
    Location:
    3q26.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (170037995..170085392)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (172822662..172870058)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (169755783..169803180)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20789 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20790 Neighboring gene FHL1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20791 Neighboring gene NANOG hESC enhancer GRCh37_chr3:169686270-169686802 Neighboring gene SEC62 homolog, preprotein translocation factor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20792 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14877 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14878 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr3:169756663-169757162 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20793 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:169763504-169764004 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20794 Neighboring gene uncharacterized LOC124909455 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20795 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20796 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20797 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:169773599-169774098 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20798 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:169779520-169780041 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:169780042-169780562 Neighboring gene MPRA-validated peak4913 silencer Neighboring gene RNA, U4 small nuclear 38, pseudogene Neighboring gene uncharacterized LOC124909456 Neighboring gene KMT5A pseudogene 3 Neighboring gene MPRA-validated peak4915 silencer Neighboring gene uncharacterized LOC105374209 Neighboring gene polyhomeotic homolog 3 Neighboring gene RNA, U6 small nuclear 315, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. GPR160 is a potential biomarker associated with prostate cancer. Guo W, et al. Signal Transduct Target Ther, 2021 Jun 25. PMID 34168114, Free PMC Article
    2. Mining of assembled expressed sequence tag (EST) data for protein families: application to the G protein-coupled receptor superfamily. Conklin D, et al. Brief Bioinform, 2000 Feb. PMID 11466977
    3. G protein-coupled receptor GPR160 is associated with apoptosis and cell cycle arrest of prostate cancer cells. Zhou C, et al. Oncotarget, 2016 Mar 15. PMID 26871479, Free PMC Article
    4. G protein-coupled receptor160 regulates mycobacteria entry into macrophages by activating ERK. Yang H, et al. Cell Signal, 2016 Sep. PMID 27259691
    5. Identification of G protein-coupled receptor genes from the human genome sequence. Takeda S, et al. FEBS Lett, 2002 Jun 5. PMID 12044878

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GPR160 is a potential biomarker associated with prostate cancer.
      Title: GPR160 is a potential biomarker associated with prostate cancer.
    2. Our data suggest that the expression level of endogenous GPR160 is associated with the pathogenesis of prostate cancer
      Title: G protein-coupled receptor GPR160 is associated with apoptosis and cell cycle arrest of prostate cancer cells.
    3. these findings suggest an important role of GPR160 in regulating the entry of BCG into macrophages by targeting the ERK signaling pathway.
      Title: G protein-coupled receptor160 regulates mycobacteria entry into macrophages by activating ERK.
    4. Observational study of gene-disease association. (HuGE Navigator)
      Title: Association of genetic variants with hemorrhagic stroke in Japanese individuals.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of receptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    probable G-protein coupled receptor 160
    Names
    G-protein coupled receptor GPCR1
    hGPCR1
    putative G protein-coupled receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014373.3 → NP_055188.1  probable G-protein coupled receptor 160

      See identical proteins and their annotated locations for NP_055188.1

      Status: VALIDATED

      Source sequence(s)
      AI560646, BC000181, BX400356, BX414005
      Consensus CDS
      CCDS3211.1
      UniProtKB/Swiss-Prot
      D3DNQ2, Q9UJ42
      Related
      ENSP00000348161.5, ENST00000355897.10

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      170037995..170085392
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024453450.2 → XP_024309218.1  probable G-protein coupled receptor 160 isoform X1

      UniProtKB/Swiss-Prot
      D3DNQ2, Q9UJ42

    2. XM_024453449.2 → XP_024309217.1  probable G-protein coupled receptor 160 isoform X1

      UniProtKB/Swiss-Prot
      D3DNQ2, Q9UJ42

    3. XM_005247346.5 → XP_005247403.1  probable G-protein coupled receptor 160 isoform X1

      See identical proteins and their annotated locations for XP_005247403.1

      UniProtKB/Swiss-Prot
      D3DNQ2, Q9UJ42

    4. XM_017006161.3 → XP_016861650.1  probable G-protein coupled receptor 160 isoform X1

      UniProtKB/Swiss-Prot
      D3DNQ2, Q9UJ42

    5. XM_047447959.1 → XP_047303915.1  probable G-protein coupled receptor 160 isoform X1

      UniProtKB/Swiss-Prot
      D3DNQ2, Q9UJ42

    6. XM_005247347.5 → XP_005247404.1  probable G-protein coupled receptor 160 isoform X1

      See identical proteins and their annotated locations for XP_005247404.1

      UniProtKB/Swiss-Prot
      D3DNQ2, Q9UJ42

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      172822662..172870058
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054346156.1 → XP_054202131.1  probable G-protein coupled receptor 160 isoform X1

      UniProtKB/Swiss-Prot
      D3DNQ2, Q9UJ42

    2. XM_054346155.1 → XP_054202130.1  probable G-protein coupled receptor 160 isoform X1

      UniProtKB/Swiss-Prot
      D3DNQ2, Q9UJ42

    3. XM_054346157.1 → XP_054202132.1  probable G-protein coupled receptor 160 isoform X1

      UniProtKB/Swiss-Prot
      D3DNQ2, Q9UJ42

    4. XM_054346158.1 → XP_054202133.1  probable G-protein coupled receptor 160 isoform X1

      UniProtKB/Swiss-Prot
      D3DNQ2, Q9UJ42
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UJ42.1 GenPept UniProtKB/Swiss-Prot:Q9UJ42

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    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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