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    FAM170A family with sequence similarity 170 member A [ Homo sapiens (human) ]

    Gene ID: 340069, updated on 27-Nov-2024

    Summary

    Official Symbol
    FAM170Aprovided by HGNC
    Official Full Name
    family with sequence similarity 170 member Aprovided by HGNC
    Primary source
    HGNC:HGNC:27963
    See related
    Ensembl:ENSG00000164334 MIM:618401; AllianceGenome:HGNC:27963
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNFD
    Summary
    Predicted to enable DNA binding activity and metal ion binding activity. Involved in positive regulation of DNA-templated transcription and transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis (RPKM 8.0) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See FAM170A in Genome Data Viewer
    Location:
    5q23.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (119629558..119635822)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (120150414..120156678)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (118965253..118971517)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986444 Neighboring gene small nucleolar RNA U13 Neighboring gene tubulin alpha pseudogene 15 Neighboring gene mitochondrial ribosomal protein L10 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC149385

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in fertilization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    protein FAM170A
    Names
    Znf domain containing protein
    zinc finger domain-containing protein
    zinc finger protein ZNFD

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163991.2NP_001157463.1  protein FAM170A isoform 2

      See identical proteins and their annotated locations for NP_001157463.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment near the N-terminus, compared to isoform 1.
      Source sequence(s)
      AC010409, AY692447
      Consensus CDS
      CCDS54889.1
      UniProtKB/TrEMBL
      D6RIE9
      Related
      ENSP00000368873.3, ENST00000379555.7
    2. NM_001367956.1NP_001354885.1  protein FAM170A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC010409, BC128243
      Consensus CDS
      CCDS93765.1
      UniProtKB/Swiss-Prot
      A1A519, Q66LM8, Q7Z4V2, Q8IW94
      UniProtKB/TrEMBL
      D6RIE9
      Related
      ENSP00000511971.1, ENST00000695508.1
    3. NM_182761.4NP_877438.2  protein FAM170A isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC010409, AY692447, BC040622
      Consensus CDS
      CCDS43353.1
      UniProtKB/TrEMBL
      D6RIE9
      Related
      ENSP00000334285.6, ENST00000335286.10

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      119629558..119635822
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      120150414..120156678
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)