U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    IL33 interleukin 33 [ Homo sapiens (human) ]

    Gene ID: 90865, updated on 3-Dec-2024

    Summary

    Official Symbol
    IL33provided by HGNC
    Official Full Name
    interleukin 33provided by HGNC
    Primary source
    HGNC:HGNC:16028
    See related
    Ensembl:ENSG00000137033 MIM:608678; AllianceGenome:HGNC:16028
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DVS27; IL1F11; NF-HEV; NFEHEV; C9orf26
    Summary
    The protein encoded by this gene is a cytokine that binds to the IL1RL1/ST2 receptor. The encoded protein is involved in the maturation of Th2 cells and the activation of mast cells, basophils, eosinophils and natural killer cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
    Expression
    Ubiquitous expression in urinary bladder (RPKM 34.7), lung (RPKM 27.3) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See IL33 in Genome Data Viewer
    Location:
    9p24.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (6215149..6257983)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (6220289..6263045)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (6215149..6257983)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902116 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28182 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28183 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:6084860-6086059 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr9:6086910-6088109 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:6106510-6107010 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:6107011-6107511 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr9:6152686-6153885 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:6166539-6167040 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:6182382-6182966 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:6182967-6183551 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28185 Neighboring gene general transcription factor IIIA pseudogene 1 Neighboring gene uncharacterized LOC107987046 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19763 Neighboring gene selenoprotein T pseudogene 1 Neighboring gene TPD52 like 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
    EBI GWAS Catalog
    A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations.
    EBI GWAS Catalog
    A large-scale, consortium-based genomewide association study of asthma.
    EBI GWAS Catalog
    Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.
    EBI GWAS Catalog
    Genome-wide association study link novel loci to endometriosis.
    EBI GWAS Catalog
    Genome-wide association study of periodontal pathogen colonization.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    In vitro infection with HIV-1 subtype B upregulates IL-33 expression in primary human astrocytes and SKNMC cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp586H0523

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cytokine activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables interleukin-33 receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in antibacterial innate immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in extrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in interleukin-33-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in macrophage differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in microglial cell activation involved in immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in microglial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of T-helper 1 type immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of immunoglobulin production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of inflammatory response to wounding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of leukocyte migration IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of macrophage proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of type II interferon production IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of CD80 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of CD86 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of MHC class I biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of MHC class II biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of cellular defense response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of chemokine production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of immunoglobulin production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of interleukin-13 production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of interleukin-4 production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of interleukin-5 production IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of positive regulation of interleukin-6 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of interleukin-6 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of macrophage activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of macrophage activation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of neuroinflammatory response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of oligodendrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    acts_upstream_of positive regulation of tumor necrosis factor production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of tumor necrosis factor production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of type 2 immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in type 2 immune response IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in transport vesicle IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    interleukin-33
    Names
    DVS27-related protein
    interleukin-1 family member 11
    nuclear factor for high endothelial venules
    nuclear factor from high endothelial venules

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047209.1 RefSeqGene

      Range
      5659..47835
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001199640.2NP_001186569.1  interleukin-33 isoform b

      See identical proteins and their annotated locations for NP_001186569.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b, also known as 2) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AB024518, AI610794, AK303943, BC047085, DB477860
      Consensus CDS
      CCDS56563.1
      UniProtKB/TrEMBL
      A0A1I9RI51
      Related
      ENSP00000414238.2, ENST00000456383.3
      Conserved Domains (1) summary
      pfam15095
      Location:5226
      IL33; Interleukin 33
    2. NM_001199641.2NP_001186570.1  interleukin-33 isoform c

      See identical proteins and their annotated locations for NP_001186570.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (c, also known as 3) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AB024518, AI610794, AK295908, BC047085
      Consensus CDS
      CCDS56564.1
      UniProtKB/TrEMBL
      A0A1I9RI50
      Related
      ENSP00000394039.2, ENST00000417746.6
      Conserved Domains (1) summary
      pfam15095
      Location:31142
      IL33; Interleukin 33
    3. NM_001314044.2NP_001300973.1  interleukin-33 isoform a precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 4, and 5 all encode the same isoform (a).
      Source sequence(s)
      AB024518, AI610794, DA713547
      Consensus CDS
      CCDS6468.1
      UniProtKB/Swiss-Prot
      B2R8L1, B4DJ35, B4E1Q9, D3DRI5, E7EAX4, O95760, Q2YEJ5
      UniProtKB/TrEMBL
      A0A1I9RI51
      Conserved Domains (1) summary
      pfam15095
      Location:5268
      IL33; Interleukin 33
    4. NM_001314045.2NP_001300974.1  interleukin-33 isoform a precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 4, and 5 all encode the same isoform (a).
      Source sequence(s)
      AB024518, AI610794, DA439244
      Consensus CDS
      CCDS6468.1
      UniProtKB/Swiss-Prot
      B2R8L1, B4DJ35, B4E1Q9, D3DRI5, E7EAX4, O95760, Q2YEJ5
      UniProtKB/TrEMBL
      A0A1I9RI51
      Conserved Domains (1) summary
      pfam15095
      Location:5268
      IL33; Interleukin 33
    5. NM_001314046.2NP_001300975.1  interleukin-33 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (d) has the same N- and C-termini but is shorter compared to isoform a. Variants 6 and 7 both encode the same isoform (d).
      Source sequence(s)
      AB024518, AI610794, DB266668
      UniProtKB/TrEMBL
      A0A1I9RI51
      Conserved Domains (1) summary
      pfam15095
      Location:5262
      IL33; Interleukin 33
    6. NM_001314047.2NP_001300976.1  interleukin-33 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (d) has the same N- and C-termini but is shorter compared to isoform a. Variants 6 and 7 both encode the same isoform (d).
      Source sequence(s)
      AB024518, AI610794, DA713547, DA719342
      UniProtKB/TrEMBL
      A0A1I9RI51
      Conserved Domains (1) summary
      pfam15095
      Location:5262
      IL33; Interleukin 33
    7. NM_001314048.2NP_001300977.1  interleukin-33 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (e) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AB024518, AI610794, DB199599, HQ641439
      Consensus CDS
      CCDS83341.1
      UniProtKB/Swiss-Prot
      O95760
      Related
      ENSP00000478858.1, ENST00000611532.4
      Conserved Domains (1) summary
      pfam15095
      Location:5226
      IL33; Interleukin 33
    8. NM_001353802.2NP_001340731.1  interleukin-33 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) lacks alternate exons in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The promoter and 5' terminal exon sequence is from an endogenous retroviral LTR (PMID: 28715472). The resulting isoform (f),has a distinct N-terminus and is shorter than isoform 1. The encoded protein is expressed in a subset of colon cancer cells.
      Source sequence(s)
      AL353741
      UniProtKB/TrEMBL
      A0A1I9RI51
      Conserved Domains (1) summary
      pfam15095
      Location:1227
      IL33; Interleukin 33
    9. NM_033439.4NP_254274.1  interleukin-33 isoform a precursor

      See identical proteins and their annotated locations for NP_254274.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a, also known as 1). Variants 1, 4, and 5 all encode the same isoform (a).
      Source sequence(s)
      AB024518, AI610794, BC047085, DB477860
      Consensus CDS
      CCDS6468.1
      UniProtKB/Swiss-Prot
      B2R8L1, B4DJ35, B4E1Q9, D3DRI5, E7EAX4, O95760, Q2YEJ5
      UniProtKB/TrEMBL
      A0A1I9RI51
      Related
      ENSP00000507310.1, ENST00000682010.1
      Conserved Domains (1) summary
      pfam15095
      Location:5268
      IL33; Interleukin 33

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      6215149..6257983
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047424062.1XP_047280018.1  interleukin-33 isoform X1

      UniProtKB/Swiss-Prot
      B2R8L1, B4DJ35, B4E1Q9, D3DRI5, E7EAX4, O95760, Q2YEJ5
      UniProtKB/TrEMBL
      A0A1I9RI51
    2. XM_017015285.2XP_016870774.1  interleukin-33 isoform X2

      UniProtKB/TrEMBL
      A0A1I9RI51
      Conserved Domains (1) summary
      pfam15095
      Location:5262
      IL33; Interleukin 33
    3. XM_047424061.1XP_047280017.1  interleukin-33 isoform X1

      UniProtKB/Swiss-Prot
      B2R8L1, B4DJ35, B4E1Q9, D3DRI5, E7EAX4, O95760, Q2YEJ5
      UniProtKB/TrEMBL
      A0A1I9RI51
    4. XM_047424064.1XP_047280020.1  interleukin-33 isoform X2

      UniProtKB/TrEMBL
      A0A1I9RI51
    5. XM_047424060.1XP_047280016.1  interleukin-33 isoform X1

      UniProtKB/Swiss-Prot
      B2R8L1, B4DJ35, B4E1Q9, D3DRI5, E7EAX4, O95760, Q2YEJ5
      UniProtKB/TrEMBL
      A0A1I9RI51
    6. XM_047424063.1XP_047280019.1  interleukin-33 isoform X2

      UniProtKB/TrEMBL
      A0A1I9RI51

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      6220289..6263045
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054364150.1XP_054220125.1  interleukin-33 isoform X1

      UniProtKB/Swiss-Prot
      B2R8L1, B4DJ35, B4E1Q9, D3DRI5, E7EAX4, O95760, Q2YEJ5
      UniProtKB/TrEMBL
      A0A1I9RI51
    2. XM_054364153.1XP_054220128.1  interleukin-33 isoform X2

      UniProtKB/TrEMBL
      A0A1I9RI51
    3. XM_054364149.1XP_054220124.1  interleukin-33 isoform X1

      UniProtKB/Swiss-Prot
      B2R8L1, B4DJ35, B4E1Q9, D3DRI5, E7EAX4, O95760, Q2YEJ5
      UniProtKB/TrEMBL
      A0A1I9RI51
    4. XM_054364152.1XP_054220127.1  interleukin-33 isoform X2

      UniProtKB/TrEMBL
      A0A1I9RI51
    5. XM_054364148.1XP_054220123.1  interleukin-33 isoform X1

      UniProtKB/Swiss-Prot
      B2R8L1, B4DJ35, B4E1Q9, D3DRI5, E7EAX4, O95760, Q2YEJ5
      UniProtKB/TrEMBL
      A0A1I9RI51
    6. XM_054364151.1XP_054220126.1  interleukin-33 isoform X2

      UniProtKB/TrEMBL
      A0A1I9RI51