HIS4 trifunctional histidinol dehydrogenase/phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: HIS4
Official Full Name: trifunctional histidinol dehydrogenase/phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase
Primary source: SGD:S000000535
Locus tag: YCL030C
See related: AllianceGenome:SGD:S000000535; FungiDB:YCL030C; VEuPathDB:YCL030C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables histidinol dehydrogenase activity; phosphoribosyl-AMP cyclohydrolase activity; and phosphoribosyl-ATP diphosphatase activity. Involved in L-histidine biosynthetic process. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See HIS4 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 1

Sequence:: Chromosome: III; NC_001135.5 (65934..68333, complement)

Chromosome III - NC_001135.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The overexpression of eIF1 improved expression of HIS4(AUG) allele and GCN4 transcript causing 3AT resistance, whereas overexpression of eIF1 resulted in diminished UUG codon recognition of HIS4(UUG) allele causing 3AT sensitivity, despite having higher GCN4 expression
Title: Fidelity of HIS4 start codon selection influences 3-amino-1,2,4-triazole sensitivity in GTPase activating protein function defective eIF5.
increase of HIS4 hotspot activity in set2 and rpd3 strains is likely to be related to the recent finding that histone H3 methylation by Set2p directs deacetylation of histones by Rpd3p
Title: The histone methylase Set2p and the histone deacetylase Rpd3p repress meiotic recombination at the HIS4 meiotic recombination hotspot in Saccharomyces cerevisiae.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables histidinol dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histidinol dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables histidinol dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables histidinol dehydrogenase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables phosphoribosyl-AMP cyclohydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphoribosyl-AMP cyclohydrolase activity	IEA Inferred from Electronic Annotation more info
enables phosphoribosyl-AMP cyclohydrolase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphoribosyl-ATP diphosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphoribosyl-ATP diphosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoribosyl-ATP diphosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in L-histidine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-histidine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in L-histidine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: trifunctional histidinol dehydrogenase/phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase

NP_009900.2

EC 1.1.1.23

EC 3.5.4.19

EC 3.6.1.31

Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase; phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001135.5 Reference assembly

Range

65934..68333 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178675.1 → NP_009900.2 TPA: trifunctional histidinol dehydrogenase/phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009900.2

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VQY5, P00815

UniProtKB/TrEMBL

B3LU52, B5VES8, C7GSY7, N1P7Z8

Conserved Domains (2) summary

PLN02346
Location:140 → 341

PLN02346; histidine biosynthesis bifunctional protein hisIE

pfam00815
Location:374 → 788

Histidinol_dh; Histidinol dehydrogenase