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    LINS1 lines homolog 1 [ Homo sapiens (human) ]

    Gene ID: 55180, updated on 27-Nov-2024

    Summary

    Official Symbol
    LINS1provided by HGNC
    Official Full Name
    lines homolog 1provided by HGNC
    Primary source
    HGNC:HGNC:30922
    See related
    Ensembl:ENSG00000140471 MIM:610350; AllianceGenome:HGNC:30922
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LINS; MRT27; WINS1
    Summary
    The Drosophila segment polarity gene lin encodes a protein, lines, which plays important roles in development of the epidermis and hindgut. This gene encodes a protein containing a lines-like domain. This gene is located on chromosome 15 and clustered with the gene encoding ankyrin repeat and SOCS box-containing protein 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2017]
    Expression
    Ubiquitous expression in lymph node (RPKM 3.7), spleen (RPKM 2.8) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See LINS1 in Genome Data Viewer
    Location:
    15q26.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (100566924..100602184, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (98321577..98357861, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (101107129..101142389, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723335 Neighboring gene PRKX pseudogene 1 Neighboring gene RNA, U6 small nuclear 181, pseudogene Neighboring gene MPRA-validated peak2454 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10170 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6877 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6878 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:101172275-101172774 Neighboring gene ankyrin repeat and SOCS box containing 7 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:101175533-101176034 Neighboring gene WD repeat domain 12 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:101209681-101210180 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10171 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10172 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10173 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr15:101253262-101254461 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:101254609-101255442 Neighboring gene uncharacterized LOC105371024 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr15:101262004-101263203 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:101305027-101305654 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:101305655-101306282 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:101308892-101309392 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr15:101322275-101322904 Neighboring gene protein enabled homolog

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates the expression of lines homolog (LINS) in human primary T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    protein Lines homolog 1
    Names
    WINS1 protein with Drosophila Lines (Lin) homologous domain
    wnt-signaling molecule Lines homolog 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_034076.2 RefSeqGene

      Range
      5849..41109
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001040616.3NP_001035706.2  protein Lines homolog 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC027020, AC090695
      Consensus CDS
      CCDS10385.1
      UniProtKB/Swiss-Prot
      Q8NG48, Q96FW2, Q9NVQ3
      Related
      ENSP00000318423.8, ENST00000314742.13
      Conserved Domains (2) summary
      pfam14694
      Location:194542
      LINES_N; Lines N-terminus
      pfam14695
      Location:712747
      LINES_C; Lines C-terminus
    2. NM_001352507.2NP_001339436.1  protein Lines homolog 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC027020, AC090695
      Conserved Domains (2) summary
      pfam14694
      Location:1293
      LINES_N; Lines N-terminus
      pfam14695
      Location:463498
      LINES_C; Lines C-terminus
    3. NM_001352508.2NP_001339437.1  protein Lines homolog 1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC027020, AC090695
      Conserved Domains (2) summary
      pfam14694
      Location:179491
      LINES_N; Lines N-terminus
      pfam14695
      Location:661696
      LINES_C; Lines C-terminus

    RNA

    1. NR_148017.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC027020, AC090695
    2. NR_148018.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC027020, AC090695
    3. NR_148019.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC027020, AC090695

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      100566924..100602184 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005254943.3XP_005255000.1  protein Lines homolog 1 isoform X2

      Conserved Domains (2) summary
      pfam14694
      Location:194506
      LINES_N; Lines N-terminus
      pfam14695
      Location:676711
      LINES_C; Lines C-terminus
    2. XM_047432784.1XP_047288740.1  protein Lines homolog 1 isoform X2

    3. XM_005254941.3XP_005254998.1  protein Lines homolog 1 isoform X1

      See identical proteins and their annotated locations for XP_005254998.1

      UniProtKB/Swiss-Prot
      Q8NG48, Q96FW2, Q9NVQ3
      Conserved Domains (2) summary
      pfam14694
      Location:194542
      LINES_N; Lines N-terminus
      pfam14695
      Location:712747
      LINES_C; Lines C-terminus
    4. XM_047432785.1XP_047288741.1  protein Lines homolog 1 isoform X2

    5. XM_024449980.2XP_024305748.1  protein Lines homolog 1 isoform X1

      UniProtKB/Swiss-Prot
      Q8NG48, Q96FW2, Q9NVQ3
      Conserved Domains (2) summary
      pfam14694
      Location:194542
      LINES_N; Lines N-terminus
      pfam14695
      Location:712747
      LINES_C; Lines C-terminus
    6. XM_017022399.3XP_016877888.1  protein Lines homolog 1 isoform X4

      Conserved Domains (2) summary
      pfam14694
      Location:1293
      LINES_N; Lines N-terminus
      pfam14695
      Location:463498
      LINES_C; Lines C-terminus
    7. XM_047432786.1XP_047288742.1  protein Lines homolog 1 isoform X3

      Related
      ENST00000559149.5
    8. XM_047432787.1XP_047288743.1  protein Lines homolog 1 isoform X3

    RNA

    1. XR_007064471.1 RNA Sequence

    2. XR_007064472.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      98321577..98357861 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054378364.1XP_054234339.1  protein Lines homolog 1 isoform X2

    2. XM_054378361.1XP_054234336.1  protein Lines homolog 1 isoform X1

    3. XM_054378362.1XP_054234337.1  protein Lines homolog 1 isoform X2

    4. XM_054378359.1XP_054234334.1  protein Lines homolog 1 isoform X1

    5. XM_054378363.1XP_054234338.1  protein Lines homolog 1 isoform X2

    6. XM_054378360.1XP_054234335.1  protein Lines homolog 1 isoform X1

    7. XM_054378367.1XP_054234342.1  protein Lines homolog 1 isoform X4

    8. XM_054378365.1XP_054234340.1  protein Lines homolog 1 isoform X3

    9. XM_054378366.1XP_054234341.1  protein Lines homolog 1 isoform X3

    RNA

    1. XR_008488984.1 RNA Sequence

    2. XR_008488985.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001040614.1: Suppressed sequence

      Description
      NM_001040614.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
    2. NM_001040615.1: Suppressed sequence

      Description
      NM_001040615.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
    3. NM_018148.4: Suppressed sequence

      Description
      NM_018148.4: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
    4. NM_181739.1: Suppressed sequence

      Description
      NM_181739.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    5. NM_181740.1: Suppressed sequence

      Description
      NM_181740.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.