U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    TM2D3 TM2 domain containing 3 [ Homo sapiens (human) ]

    Gene ID: 80213, updated on 9-Dec-2024

    Summary

    Official Symbol
    TM2D3provided by HGNC
    Official Full Name
    TM2 domain containing 3provided by HGNC
    Primary source
    HGNC:HGNC:24128
    See related
    Ensembl:ENSG00000184277 MIM:610014; AllianceGenome:HGNC:24128
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BLP2
    Summary
    The protein encoded by this gene contains a structural module related to that of the seven transmembrane domain G protein-coupled receptor superfamily. This protein has sequence and structural similarities to the beta-amyloid binding protein (BBP), but, unlike BBP, it does not regulate a response to beta-amyloid peptide. This protein may have regulatory roles in cell death or proliferation signal cascades. Several alternatively spliced transcript variants of this gene are described but the full length nature of some variants has not been determined. Multiple polyadenylation sites have been found in this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 24.1), ovary (RPKM 18.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TM2D3 in Genome Data Viewer
    Location:
    15q26.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (101632977..101652381, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (99378569..99410385, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (102173180..102192584, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene small nuclear ribonucleoprotein polypeptide C pseudogene 18 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr15:102119493-102120692 Neighboring gene long intergenic non-protein coding RNA 2348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:102152533-102153033 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:102153852-102154370 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:102154371-102154887 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:102157328-102157940 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6891 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:102186842-102187008 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6892 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10195 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:102192988-102193878 Neighboring gene RNA, U6 small nuclear 807, pseudogene Neighboring gene threonyl-tRNA synthetase 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:102215750-102216274 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:102216275-102216797 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6894 Neighboring gene UBE2Q2 pseudogene 13

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in lateral inhibition IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in lateral inhibition ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of Notch signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    PubMed 

    General protein information

    Preferred Names
    TM2 domain-containing protein 3
    Names
    BBP-like protein 2
    almondex homolog
    beta-amyloid-binding protein-like protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001307960.2NP_001294889.1  TM2 domain-containing protein 3 isoform c precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the 5' coding region and uses an alternate terminal exon compared to variant 1. The encoded isoform (c) is shorter and has a distinct C-terminus compared to isoform a.
      Source sequence(s)
      AC090164, AK297048
      Consensus CDS
      CCDS76795.1
      UniProtKB/TrEMBL
      B4DLL2, E7EPS7
      Related
      ENSP00000402179.2, ENST00000428002.6
    2. NM_001308026.2NP_001294955.1  TM2 domain-containing protein 3 isoform d precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate terminal exon compared to variant 1. The encoded isoform (d) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC090164, AK297048, BM984342, BU595412
      Consensus CDS
      CCDS76796.1
      UniProtKB/TrEMBL
      B4DLL2, H0YNS4
      Related
      ENSP00000454131.1, ENST00000559107.5
    3. NM_025141.4NP_079417.2  TM2 domain-containing protein 3 isoform b precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon within the coding region, but maintains the same reading frame, as compared to variant 1. Thus isoform b lacks an internal fragment of 26 aa compared to isoform a.
      Source sequence(s)
      AC090164, BQ272585
      Consensus CDS
      CCDS10392.1
      UniProtKB/TrEMBL
      B3KT51
      Related
      ENSP00000327584.3, ENST00000347970.7
      Conserved Domains (1) summary
      pfam05154
      Location:156205
      TM2; TM2 domain
    4. NM_078474.3NP_510883.2  TM2 domain-containing protein 3 isoform a precursor

      See identical proteins and their annotated locations for NP_510883.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the full length isoform.
      Source sequence(s)
      AC090164, BC006150
      Consensus CDS
      CCDS10393.1
      UniProtKB/Swiss-Prot
      B2RDK9, Q9BRN9, Q9H046, Q9H651
      Related
      ENSP00000330433.3, ENST00000333202.8
      Conserved Domains (1) summary
      pfam05154
      Location:182231
      TM2; TM2 domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      101632977..101652381 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      99378569..99410385 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_008489017.1 RNA Sequence

    2. XR_008489016.1 RNA Sequence

    3. XR_008489015.1 RNA Sequence

    4. XR_008489014.1 RNA Sequence