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    TAPBP TAP binding protein [ Homo sapiens (human) ]

    Gene ID: 6892, updated on 3-Dec-2024

    Summary

    Official Symbol
    TAPBPprovided by HGNC
    Official Full Name
    TAP binding proteinprovided by HGNC
    Primary source
    HGNC:HGNC:11566
    See related
    Ensembl:ENSG00000231925 MIM:601962; AllianceGenome:HGNC:11566
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TPN; TAPA; TPSN; NGS17; MHC1D3
    Summary
    This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in spleen (RPKM 38.1), appendix (RPKM 25.3) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TAPBP in Genome Data Viewer
    Location:
    6p21.32
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (33299694..33314078, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (33121056..33135440, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (33267471..33281855, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene WD repeat domain 46 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33255009-33255542 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33255543-33256076 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:33256611-33257144 Neighboring gene microRNA 6873 Neighboring gene microRNA 6834 Neighboring gene prefoldin subunit 6 Neighboring gene ral guanine nucleotide dissociation stimulator like 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:33265070-33265597 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33265684-33266184 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:33266952-33267130 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:33267887-33268394 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33268395-33268900 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:33282409-33283068 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:33283069-33283726 Neighboring gene zinc finger and BTB domain containing 22 Neighboring gene uncharacterized LOC124901303 Neighboring gene death domain associated protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with TAPBP; predicted interaction to be involved in antigenicity/immunity PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables MHC class I protein binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables MHC class I protein complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables TAP complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables TAP complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables TAP1 binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables TAP1 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables TAP1 binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables TAP2 binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables TAP2 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables TAP2 binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables molecular adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptide antigen binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein folding chaperone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables unfolded protein binding TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    tapasin
    Names
    NGS-17
    TAP binding protein (tapasin)
    TAP-associated protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_009876.1 RefSeqGene

      Range
      4826..19519
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_114

    mRNA and Protein(s)

    1. NM_001410875.1NP_001397804.1  tapasin isoform 4 precursor

      Status: REVIEWED

      Source sequence(s)
      AL662820
      Consensus CDS
      CCDS93889.1
      UniProtKB/TrEMBL
      A0A0G2JKZ1, A0A8V8TQC5
      Related
      ENSP00000514506.1, ENST00000699657.1
    2. NM_003190.5NP_003181.3  tapasin isoform 1 precursor

      See identical proteins and their annotated locations for NP_003181.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
      Source sequence(s)
      AB010639, AF029750, AL662820
      Consensus CDS
      CCDS34426.1
      UniProtKB/Swiss-Prot
      A2AB91, A2ABC0, B0V003, B0V0A6, B2ZUA4, E9PGM2, O15210, O15272, O15533, Q5STJ8, Q5STK6, Q5STQ5, Q5STQ6, Q66K65, Q96KK7, Q9HAN8, Q9UEE0, Q9UEE4, Q9UIZ6, Q9Y6K2
      UniProtKB/TrEMBL
      A0A024RCT1, A0A0G2JKZ1
      Related
      ENSP00000395701.2, ENST00000434618.7
      Conserved Domains (1) summary
      cl11960
      Location:260391
      Ig; Immunoglobulin domain
    3. NM_172208.3NP_757345.2  tapasin isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is longer than isoform 1.
      Source sequence(s)
      AL662820, AU117273, AW028178, BC080574
      Consensus CDS
      CCDS34428.2
      UniProtKB/TrEMBL
      A0A0A0MSV9, A0A0G2JKZ1
      Related
      ENSP00000404833.2, ENST00000426633.6
      Conserved Domains (1) summary
      cl11960
      Location:255391
      Ig; Immunoglobulin domain
    4. NM_172209.3NP_757346.2  tapasin isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
      Source sequence(s)
      AF029750, AL662820, AU117273, EU693375
      Consensus CDS
      CCDS34427.2
      UniProtKB/TrEMBL
      A0A0A0MT98, A0A0G2JKZ1
      Related
      ENSP00000419659.1, ENST00000489157.6
      Conserved Domains (1) summary
      cl11960
      Location:168304
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      33299694..33314078 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047419272.1XP_047275228.1  tapasin isoform X3

    2. XM_047419271.1XP_047275227.1  tapasin isoform X2

    3. XM_011514828.4XP_011513130.1  tapasin isoform X1

      See identical proteins and their annotated locations for XP_011513130.1

      UniProtKB/TrEMBL
      A0A0G2JKZ1
      Conserved Domains (1) summary
      cl11960
      Location:255391
      Ig; Immunoglobulin domain

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NT_113891.3 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      4711179..4725561 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054329858.1XP_054185833.1  tapasin isoform X3

    2. XM_054329857.1XP_054185832.1  tapasin isoform X2

    3. XM_054329856.1XP_054185831.1  tapasin isoform X1

      UniProtKB/TrEMBL
      A0A0G2JKZ1

    Reference GRCh38.p14 ALT_REF_LOCI_3

    Genomic

    1. NT_167245.2 Reference GRCh38.p14 ALT_REF_LOCI_3

      Range
      4543212..4557593 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330341.1XP_054186316.1  tapasin isoform X3

    2. XM_054330340.1XP_054186315.1  tapasin isoform X2

    3. XM_054330339.1XP_054186314.1  tapasin isoform X1

      UniProtKB/TrEMBL
      A0A0G2JKZ1

    Reference GRCh38.p14 ALT_REF_LOCI_5

    Genomic

    1. NT_167247.2 Reference GRCh38.p14 ALT_REF_LOCI_5

      Range
      4735630..4750012 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330857.1XP_054186832.1  tapasin isoform X3

    2. XM_054330856.1XP_054186831.1  tapasin isoform X2

    3. XM_054330855.1XP_054186830.1  tapasin isoform X1

      UniProtKB/TrEMBL
      A0A0G2JKZ1

    Reference GRCh38.p14 ALT_REF_LOCI_6

    Genomic

    1. NT_167248.2 Reference GRCh38.p14 ALT_REF_LOCI_6

      Range
      4494115..4508505 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331118.1XP_054187093.1  tapasin isoform X2

    2. XM_054331117.1XP_054187092.1  tapasin isoform X1

      UniProtKB/TrEMBL
      A0A0G2JKZ1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      33121056..33135440 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054356273.1XP_054212248.1  tapasin isoform X3

    2. XM_054356272.1XP_054212247.1  tapasin isoform X2

    3. XM_054356271.1XP_054212246.1  tapasin isoform X1

      UniProtKB/TrEMBL
      A0A0G2JKZ1