ADGRL4 adhesion G protein-coupled receptor L4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ADGRL4provided by HGNC
Official Full Name: adhesion G protein-coupled receptor L4provided by HGNC
Primary source: HGNC:HGNC:20822
See related: Ensembl:ENSG00000162618 MIM:616419; AllianceGenome:HGNC:20822
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ETL; ELTD1; KPG_003
Summary: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in cytoplasmic vesicle. Predicted to be active in plasma membrane. Biomarker of glioblastoma and hypertrophic cardiomyopathy. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in fat (RPKM 38.7), spleen (RPKM 20.4) and 20 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p31.1

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (78889764..79006730, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (78728626..78845196, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (79355449..79472415, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ADGRL4/ELTD1 Expression in Breast Cancer Cells Induces Vascular Normalization and Immune Suppression.
Title: ADGRL4/ELTD1 Expression in Breast Cancer Cells Induces Vascular Normalization and Immune Suppression.
ELTD1 deletion reduces vascular abnormality and improves T-cell recruitment after PD-1 blockade in glioma.
Title: ELTD1 deletion reduces vascular abnormality and improves T-cell recruitment after PD-1 blockade in glioma.
ELTD1 promotes invasion and metastasis by activating MMP2 in colorectal cancer.
Title: ELTD1 promotes invasion and metastasis by activating MMP2 in colorectal cancer.
ELTD1 Activation Induces an Endothelial-EMT Transition to a Myofibroblast Phenotype.
Title: ELTD1 Activation Induces an Endothelial-EMT Transition to a Myofibroblast Phenotype.
Elevated expression of the adhesion GPCR ADGRL4/ELTD1 promotes endothelial sprouting angiogenesis without activating canonical GPCR signalling.
Title: Elevated expression of the adhesion GPCR ADGRL4/ELTD1 promotes endothelial sprouting angiogenesis without activating canonical GPCR signalling.
Adhesion G protein-coupled receptor, ELTD1, is a potential therapeutic target for retinoblastoma migration and invasion.
Title: Adhesion G protein-coupled receptor, ELTD1, is a potential therapeutic target for retinoblastoma migration and invasion.
ELTD1 facilitates glioma proliferation, migration and invasion by activating JAK/STAT3/HIF-1alpha signaling axis.
Title: ELTD1 facilitates glioma proliferation, migration and invasion by activating JAK/STAT3/HIF-1α signaling axis.
High ELTD1 expression is associated with glioma.
Title: ELTD1, an effective anti-angiogenic target for gliomas: preclinical assessment in mouse GL261 and human G55 xenograft glioma models.
miR-139-5p suppresses glioblastoma multiforme cell proliferation by targeting ELTD1 and regulating cell cycle.
Title: MicroRNA-139-5p acts as a tumor suppressor by targeting ELTD1 and regulating cell cycle in glioblastoma multiforme.
Results provide insight into the regulation of tumor angiogenesis and highlight ELTD1 as key player in blood vessel formation.
Title: A core human primary tumor angiogenesis signature identifies the endothelial orphan receptor ELTD1 as a key regulator of angiogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH103500 (e-PCR)
- UniSTS:97825

RH121699 (e-PCR)
- UniSTS:134438

RH103250 (e-PCR)
- UniSTS:97582

RH70233 (e-PCR)
- UniSTS:876

SHGC-79628 (e-PCR)
- UniSTS:104604

SHGC-57820 (e-PCR)
- UniSTS:44286

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	TAS Traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: adhesion G protein-coupled receptor L4

Names: EGF, latrophilin and seven transmembrane domain containing 1; EGF, latrophilin and seven transmembrane domain-containing protein 1; EGF-TM7-latrophilin-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022159.4 → NP_071442.2 adhesion G protein-coupled receptor L4 precursor

See identical proteins and their annotated locations for NP_071442.2

Status: VALIDATED

Source sequence(s)

AB032017, AC099674, AK129766, DA477962

Consensus CDS

CCDS41352.1

UniProtKB/Swiss-Prot

B1AR71, Q5KU34, Q9HBW9

UniProtKB/TrEMBL

A8KA29

Related

ENSP00000359778.3, ENST00000370742.4

Conserved Domains (4) summary

pfam01825
Location:368 → 412

GPS; GPCR proteolysis site, GPS, motif

pfam07645
Location:58 → 91

EGF_CA; Calcium-binding EGF domain

pfam16489
Location:139 → 330

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

cl21561
Location:424 → 660

7tm_4; Olfactory receptor