GAL3ST2 galactose-3-O-sulfotransferase 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GAL3ST2provided by HGNC
Official Full Name: galactose-3-O-sulfotransferase 2provided by HGNC
Primary source: HGNC:HGNC:24869
See related: Ensembl:ENSG00000154252 MIM:608237; AllianceGenome:HGNC:24869
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GP3ST; GAL3ST-2
Summary: This gene encodes a member of the galactose-3-O-sulfotransferase protein family. The product of this gene catalyzes sulfonation by transferring a sulfate group to the hydroxyl at C-3 of nonreducing beta-galactosyl residues, and it can act on both type 1 and type 2 (Galbeta 1-3/1-4GlcNAc-R) oligosaccharides with similar efficiencies, and on core 1 glycans. This enzyme has been implicated in tumor metastasis processes. This gene is different from the GAL3ST3 gene located on chromosome 11, which has also been referred to as GAL3ST2 and encodes a related enzyme with distinct tissue distribution and substrate specificities, compared to galactose-3-O-sulfotransferase 2. [provided by RefSeq, Jul 2008]
Expression: Restricted expression toward colon (RPKM 8.9) See more
Orthologs: all
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Genomic context

Location:: 2q37.3

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (241776822..241804287)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (242279352..242306816)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (242716237..242743702)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

D2HGDH-GAL3ST2 is more frequently seen in prostate cancer samples, and seems to be enriched in African Americans.
Title: Recurrent cis-SAGe chimeric RNA, D2HGDH-GAL3ST2, in prostate cancer.
GAL3ST2 is present in breast cancer cell lines and is more strongly expressed in more metastatic tumors.
Title: GAL3ST2 from mammary gland epithelial cells affects differentiation of 3T3-L1 preadipocytes.
Gal3ST-2 is involved in tumor metastasis process by regulation of adhesion ability to selectins and expression of integrin alphaV but not beta3
Title: Gal3ST-2 involved in tumor metastasis process by regulation of adhesion ability to selectins and expression of integrins.
The substrate specificity and cofactor requirements of human, porcine, and murine GAL3ST are reported
Title: Porcine, mouse and human galactose 3-O-sulphotransferase-2 enzymes have different substrate specificities; the porcine enzyme requires basic compounds for its catalytic activity.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables galactose 3-O-sulfotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables galactosylceramide sulfotransferase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sulfotransferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in glycolipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in glycoprotein biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi cisterna membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: galactose-3-O-sulfotransferase 2

Names: beta-galactose-3-O-sulfotransferase 2; gal 3-O-sulphotransferase; gal-beta-1, 3-GalNAc 3'-sulfotransferase 2; galbeta1-3GalNAc 3'-sulfotransferase 2; glycoprotein beta-Gal 3'-sulfotransferase 2

NP_071417.2

EC 2.8.2.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.