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    GPRASP1 G protein-coupled receptor associated sorting protein 1 [ Homo sapiens (human) ]

    Gene ID: 9737, updated on 9-Dec-2024

    Summary

    Official Symbol
    GPRASP1provided by HGNC
    Official Full Name
    G protein-coupled receptor associated sorting protein 1provided by HGNC
    Primary source
    HGNC:HGNC:24834
    See related
    Ensembl:ENSG00000198932 MIM:300417; AllianceGenome:HGNC:24834
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GASP; GASP1; GASP-1
    Summary
    This gene encodes a member of the GPRASP (G protein-coupled receptor associated sorting protein) family. The protein may modulate lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. It targets receptors for degradation in lysosomes. The receptors interacting with this sorting protein include D2 dopamine receptor (DRD2), delta opioid receptor (OPRD1), beta-2 adrenergic receptor (ADRB2), D4 dopamine receptor (DRD4) and cannabinoid 1 receptor (CB1R). Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, May 2010]
    Expression
    Broad expression in brain (RPKM 27.6), ovary (RPKM 20.3) and 21 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See GPRASP1 in Genome Data Viewer
    Location:
    Xq22.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (102651483..102659083)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (101096438..101104038)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (101906411..101914011)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ARMCX5-GPRASP2 readthrough Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:101854489-101855260 Neighboring gene armadillo repeat containing X-linked 5 Neighboring gene H3 histone pseudogene 45 Neighboring gene RNA, U6 small nuclear 589, pseudogene Neighboring gene BEN domain containing 7 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Readthrough ARMCX5-GPRASP2

    Readthrough gene: ARMCX5-GPRASP2, Included gene: ARMCX5, Included gene: GPRASP3, Included gene: GPRASP2, Included gene: LINC00630

    Clone Names

    • KIAA0443

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    G-protein coupled receptor-associated sorting protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021332.1 RefSeqGene

      Range
      5118..12718
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001099410.2NP_001092880.1  G-protein coupled receptor-associated sorting protein 1

      See identical proteins and their annotated locations for NP_001092880.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5' UTR and encodes the same protein, as compared to variant 1.
      Source sequence(s)
      AW293629, AY044233, BC114552, DA104338
      Consensus CDS
      CCDS35352.1
      UniProtKB/Swiss-Prot
      O43168, Q5JY77, Q96LA1
      Related
      ENSP00000393691.1, ENST00000415986.5
      Conserved Domains (1) summary
      pfam04826
      Location:11671390
      Arm_2; Armadillo-like
    2. NM_001099411.2NP_001092881.1  G-protein coupled receptor-associated sorting protein 1

      See identical proteins and their annotated locations for NP_001092881.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two exons in the 5' UTR and encodes the same protein, as compared to variant 1.
      Source sequence(s)
      AW293629, AY044233, BC114552, DA094297
      Consensus CDS
      CCDS35352.1
      UniProtKB/Swiss-Prot
      O43168, Q5JY77, Q96LA1
      Related
      ENSP00000409420.1, ENST00000444152.5
      Conserved Domains (1) summary
      pfam04826
      Location:11671390
      Arm_2; Armadillo-like
    3. NM_001184727.2NP_001171656.1  G-protein coupled receptor-associated sorting protein 1

      See identical proteins and their annotated locations for NP_001171656.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has an additional exon in the 5' UTR and encodes the same protein, as compared to variant 1.
      Source sequence(s)
      AW293629, AY044233, BC114552, BX489726, BX954816
      Consensus CDS
      CCDS35352.1
      UniProtKB/Swiss-Prot
      O43168, Q5JY77, Q96LA1
      Related
      ENSP00000445683.1, ENST00000537097.2
      Conserved Domains (1) summary
      pfam04826
      Location:11671390
      Arm_2; Armadillo-like
    4. NM_014710.5NP_055525.3  G-protein coupled receptor-associated sorting protein 1

      See identical proteins and their annotated locations for NP_055525.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents a dominant transcript. Variants 1-4 encode the same protein.
      Source sequence(s)
      AW293629, AY044233, BC114552, DA222893
      Consensus CDS
      CCDS35352.1
      UniProtKB/Swiss-Prot
      O43168, Q5JY77, Q96LA1
      Related
      ENSP00000355146.4, ENST00000361600.9
      Conserved Domains (1) summary
      pfam04826
      Location:11671390
      Arm_2; Armadillo-like

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      102651483..102659083
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      101096438..101104038
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)