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    RPC37 DNA-directed RNA polymerase III subunit C37 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853895, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RPC37
    Official Full Name
    DNA-directed RNA polymerase III subunit C37
    Primary source
    SGD:S000001733
    Locus tag
    YKR025W
    See related
    AllianceGenome:SGD:S000001733; FungiDB:YKR025W; VEuPathDB:YKR025W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to RNA polymerase III activity. Involved in tRNA transcription by RNA polymerase III. Part of RNA polymerase III complex. Orthologous to human POLR3E (RNA polymerase III subunit E). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RPC37 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (487770..488618)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Rqt4p Neighboring gene putative ATP-dependent RNA helicase Neighboring gene translation initiation factor eIF2B subunit alpha Neighboring gene tRNA-Arg

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A subcomplex of RNA polymerase III subunits involved in transcription termination and reinitiation. Landrieux E, et al. EMBO J, 2006 Jan 11. PMID 16362040, Free PMC Article
    2. The C53/C37 subcomplex of RNA polymerase III lies near the active site and participates in promoter opening. Kassavetis GA, et al. J Biol Chem, 2010 Jan 22. PMID 19940126, Free PMC Article
    3. Distinguishing core and holoenzyme mechanisms of transcription termination by RNA polymerase III. Arimbasseri AG, et al. Mol Cell Biol, 2013 Apr. PMID 23401852, Free PMC Article
    4. Mechanism of Transcription Termination by RNA Polymerase III Utilizes a Non-template Strand Sequence-Specific Signal Element. Arimbasseri AG, et al. Mol Cell, 2015 Jun 18. PMID 25959395, Free PMC Article
    5. A Region of Bdp1 Necessary for Transcription Initiation That Is Located within the RNA Polymerase III Active Site Cleft. Hu HL, et al. Mol Cell Biol, 2015 Aug. PMID 26055328, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Date indicate that RNA Polymerase III (RNAP III) subunits C53, C37, and C11 are required for pre-termination complex (PTC) formation.
      Title: Mechanism of Transcription Termination by RNA Polymerase III Utilizes a Non-template Strand Sequence-Specific Signal Element.
    2. C53/C37 subcomplex additionally plays a role in formation of the initiation-ready open promoter complex
      Title: The C53/C37 subcomplex of RNA polymerase III lies near the active site and participates in promoter opening.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to RNA polymerase III activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA transcription by RNA polymerase III IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DNA-directed RNA polymerase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of RNA polymerase III complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA-directed RNA polymerase III subunit C37
    NP_012950.3
    • RNA polymerase III subunit C37

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      487770..488618
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179815.3 → NP_012950.3  TPA: DNA-directed RNA polymerase III subunit C37 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012950.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VX90, P36121
      UniProtKB/TrEMBL
      B5VMH3, C7GNN4, C8ZCI9, G2WI56, N1P823
      Conserved Domains (1) summary
      pfam04801
      Location:69 → 247
      Sin_N; Sin-like protein conserved region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36121.1

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