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    PIG1 protein phosphatase regulator PIG1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850979, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PIG1
    Official Full Name
    protein phosphatase regulator PIG1
    Primary source
    SGD:S000004263
    Locus tag
    YLR273C
    See related
    AllianceGenome:SGD:S000004263; FungiDB:YLR273C; VEuPathDB:YLR273C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein phosphatase regulator activity. Involved in regulation of glycogen biosynthetic process. Predicted to be part of protein phosphatase type 1 complex. Orthologous to human PPP1R3E (protein phosphatase 1 regulatory subunit 3E). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PIG1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (689083..691029, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene condensin subunit YCS4 Neighboring gene tRNA-Val Neighboring gene MCM DNA helicase complex subunit MCM5 Neighboring gene mRNA splicing protein SMD2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast PIG genes: PIG1 encodes a putative type 1 phosphatase subunit that interacts with the yeast glycogen synthase Gsy2p. Cheng C, et al. Yeast, 1997 Jan. PMID 9046081
    2. Identification of novel genes involved in neutral lipid storage by quantitative trait loci analysis of Saccharomyces cerevisiae. Pačnik K, et al. BMC Genomics, 2021 Feb 9. PMID 33563210, Free PMC Article
    3. Glucose-induced posttranslational activation of protein phosphatases PP2A and PP1 in yeast. Castermans D, et al. Cell Res, 2012 Jun. PMID 22290422, Free PMC Article
    4. Genetic interactions between GLC7, PPZ1 and PPZ2 in saccharomyces cerevisiae. Venturi GM, et al. Genetics, 2000 May. PMID 10790385, Free PMC Article
    5. Early steps in autophagy depend on direct phosphorylation of Atg9 by the Atg1 kinase. Papinski D, et al. Mol Cell, 2014 Feb 6. PMID 24440502, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables glycogen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase 1 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase regulator activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables protein phosphatase regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glycogen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of glycogen biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of glycogen biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of protein phosphatase type 1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein phosphatase type 1 complex ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein phosphatase regulator PIG1
    NP_013375.1
    • Putative targeting subunit for type-1 protein phosphatase Glc7p; tethers Glc7p to Gsy2p glycogen synthase; PIG1 has a paralog, GAC1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      689083..691029 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182160.1 → NP_013375.1  TPA: protein phosphatase regulator PIG1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013375.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYS0, E9P964, Q06216
      UniProtKB/TrEMBL
      C7GVT6
      Conserved Domains (1) summary
      pfam03370
      Location:192 → 331
      CBM_21; Carbohydrate/starch-binding module (family 21)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06216.1

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