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    Csnk1a1 casein kinase 1, alpha 1 [ Mus musculus (house mouse) ]

    Gene ID: 93687, updated on 4-Jan-2025

    Summary

    Official Symbol
    Csnk1a1provided by MGI
    Official Full Name
    casein kinase 1, alpha 1provided by MGI
    Primary source
    MGI:MGI:1934950
    See related
    Ensembl:ENSMUSG00000024576 AllianceGenome:MGI:1934950
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CK1a; Csnk1a; 2610208K14Rik; 4632404G05Rik; 5430427P18Rik
    Summary
    Enables protein serine/threonine kinase activity. Involved in negative regulation of NLRP3 inflammasome complex assembly and protein phosphorylation. Acts upstream of or within cell morphogenesis. Located in ciliary basal body and spindle. Part of ribonucleoprotein complex. Is expressed in several structures, including central nervous system; endocrine gland; metanephros; retina nuclear layer; and thymus primordium. Orthologous to human CSNK1A1 (casein kinase 1 alpha 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 23.9), bladder adult (RPKM 23.5) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Csnk1a1 in Genome Data Viewer
    Location:
    18 E1; 18 34.62 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (61687307..61723391)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (61554236..61590320)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46637 Neighboring gene Rho guanine nucleotide exchange factor 37 Neighboring gene STARR-seq mESC enhancer starr_44745 Neighboring gene STARR-seq mESC enhancer starr_44746 Neighboring gene STARR-positive B cell enhancer ABC_E9979 Neighboring gene STARR-seq mESC enhancer starr_44748 Neighboring gene VISTA enhancer mm36 Neighboring gene STARR-seq mESC enhancer starr_44754 Neighboring gene predicted gene, 41747 Neighboring gene STARR-seq mESC enhancer starr_44755 Neighboring gene predicted gene, 35607

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC29354, MGC30571

    Gene Ontology Provided by MGI

    Items 1 - 25 of 32
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding  
    enables ATP binding  
    enables DNA-dependent protein kinase activity  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables magnesium ion binding  
    enables peptide binding  
    enables phosphoprotein binding  
    enables protein kinase activity PubMed 
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    enables ribosomal protein S6 kinase activity  
    Items 1 - 25 of 32
    Process Evidence Code Pubs
    involved_in Golgi organization  
    involved_in Golgi organization  
    involved_in Wnt signaling pathway  
    involved_in cell division  
    acts_upstream_of_or_within cell morphogenesis PubMed 
    involved_in cellular response to nutrient  
    involved_in chromatin remodeling  
    involved_in intermediate filament cytoskeleton organization  
    involved_in intermediate filament cytoskeleton organization  
    involved_in negative regulation of NLRP3 inflammasome complex assembly PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway  
    involved_in negative regulation of canonical Wnt signaling pathway  
    involved_in peptidyl-serine phosphorylation  
    involved_in peptidyl-serine phosphorylation  
    involved_in positive regulation of Rho protein signal transduction  
    involved_in positive regulation of TORC1 signaling  
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process  
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process PubMed 
    involved_in protein phosphorylation PubMed 
    involved_in protein phosphorylation  
    involved_in signal transduction  
    Component Evidence Code Pubs
    part_of beta-catenin destruction complex  
    part_of beta-catenin destruction complex  
    part_of beta-catenin destruction complex PubMed 
    located_in centrosome  
    located_in centrosome  
    located_in ciliary basal body PubMed 
    located_in cilium  
    is_active_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    colocalizes_with keratin filament  
    colocalizes_with keratin filament  
    located_in kinetochore  
    part_of mRNA cleavage and polyadenylation specificity factor complex  
    part_of mRNA cleavage and polyadenylation specificity factor complex  
    located_in nuclear speck  
    located_in nuclear speck  
    is_active_in nucleus  
    part_of ribonucleoprotein complex PubMed 
    located_in spindle PubMed 

    General protein information

    Preferred Names
    casein kinase I isoform alpha; casein kinase I
    Names
    CK1
    CKI-alpha
    casein kinase I-alpha
    NP_001344427.1
    NP_001344428.1
    NP_001344429.1
    NP_666199.1
    XP_006526446.1
    XP_006526449.1
    XP_011245350.1
    XP_030106505.1
    XP_030106506.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357498.1NP_001344427.1  casein kinase I isoform alpha isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC153155, AI853067
      Consensus CDS
      CCDS89252.1
      UniProtKB/TrEMBL
      E9Q3W1, Q3U772
      Related
      ENSMUSP00000127265.2, ENSMUST00000170862.8
      Conserved Domains (1) summary
      cd14128
      Location:16309
      STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha
    2. NM_001357499.1NP_001344428.1  casein kinase I isoform alpha isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC153155, AI853067
      Consensus CDS
      CCDS89251.1
      UniProtKB/TrEMBL
      E9Q2U6, Q3U844
      Related
      ENSMUSP00000127463.2, ENSMUST00000167187.8
      Conserved Domains (1) summary
      cd14128
      Location:16309
      STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha
    3. NM_001357500.1NP_001344429.1  casein kinase I isoform alpha isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC153155, AI853067
      Consensus CDS
      CCDS89254.1
      UniProtKB/Swiss-Prot
      Q3UIL0, Q64506, Q80XI2, Q8BK63, Q99LY3
      UniProtKB/TrEMBL
      Q3U772
      Related
      ENSMUSP00000132083.2, ENSMUST00000165721.8
      Conserved Domains (1) summary
      cd14128
      Location:16281
      STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha
    4. NM_146087.3NP_666199.1  casein kinase I isoform alpha isoform 1

      See identical proteins and their annotated locations for NP_666199.1

      Status: VALIDATED

      Source sequence(s)
      AC153155, AI853067, AK076070, AK146873, BY065893
      Consensus CDS
      CCDS37838.1
      UniProtKB/TrEMBL
      Q3U844, Q6PJ87
      Related
      ENSMUSP00000128871.2, ENSMUST00000165123.8
      Conserved Domains (1) summary
      cd14128
      Location:16281
      STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      61687307..61723391
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247048.3XP_011245350.1  casein kinase I isoform X1

      UniProtKB/TrEMBL
      Q3U772
      Conserved Domains (1) summary
      cd14128
      Location:16309
      STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha
    2. XM_006526383.4XP_006526446.1  casein kinase I isoform X2

      UniProtKB/TrEMBL
      Q3U772
      Conserved Domains (1) summary
      cd14128
      Location:16309
      STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha
    3. XM_006526386.4XP_006526449.1  casein kinase I isoform X3

      UniProtKB/TrEMBL
      Q3U844
      Conserved Domains (1) summary
      cd14128
      Location:16309
      STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha
    4. XM_030250645.1XP_030106505.1  casein kinase I isoform X4

      UniProtKB/TrEMBL
      Q3U772
      Related
      ENSMUSP00000127144.2, ENSMUST00000163205.8
      Conserved Domains (1) summary
      cd14128
      Location:16281
      STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha
    5. XM_030250646.1XP_030106506.1  casein kinase I isoform X5

      UniProtKB/TrEMBL
      H7BXB1, Q3U844
      Related
      ENSMUSP00000110901.3, ENSMUST00000115246.9
      Conserved Domains (1) summary
      cd14128
      Location:16281
      STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha

    RNA

    1. XR_386022.4 RNA Sequence

    2. XR_386023.4 RNA Sequence

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