EPT1 bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: EPT1
Official Full Name: bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase
Primary source: SGD:S000001165
Locus tag: YHR123W
See related: AllianceGenome:SGD:S000001165; FungiDB:YHR123W; VEuPathDB:YHR123W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables diacylglycerol cholinephosphotransferase activity and ethanolaminephosphotransferase activity. Involved in phosphatidylcholine biosynthetic process and phosphatidylethanolamine biosynthetic process. Located in Golgi apparatus and endoplasmic reticulum. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 81. Orthologous to several human genes including SELENOI (selenoprotein I). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See EPT1 in Genome Data Viewer

Location:: chromosome: VIII

Exon count:: 2

Sequence:: Chromosome: VIII; NC_001140.6 (354815..356081)

Chromosome VIII - NC_001140.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables diacylglycerol cholinephosphotransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables diacylglycerol cholinephosphotransferase activity	IEA Inferred from Electronic Annotation more info
enables diacylglycerol cholinephosphotransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ethanolaminephosphotransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables ethanolaminephosphotransferase activity	IEA Inferred from Electronic Annotation more info
enables ethanolaminephosphotransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphotransferase activity, for other substituted phosphate groups	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in CDP-choline pathway	IEA Inferred from Electronic Annotation more info
involved_in lipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylcholine biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylcholine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylcholine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylethanolamine biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylethanolamine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylethanolamine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phospholipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	HDA more info	PubMed
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	HDA more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase

NP_011991.1

EC 2.7.8.1

EC 2.7.8.2

sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability; EPT1 has a paralog, CPT1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001140.6 Reference assembly

Range

354815..356081

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179253.1 → NP_011991.1 TPA: bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011991.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DL73, P22140

UniProtKB/TrEMBL

B3LSN8, C8Z9R6, N1P9F5

Conserved Domains (1) summary

COG5050
Location:2 → 391

EPT1; sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferases [Lipid metabolism]